To compare visual and anatomical outcomes between peeling and embedding of epiretinal proliferation in patients with full-thickness macular holes (FTMH) with epiretinal proliferation (EP), this retrospective cohort study classified patients into two groups based on whether EP was completely peeled (peeling group, n = 25 eyes), or embedded into the hole (embedding group, n = 31 eyes) during surgery. Preoperative characteristics and postoperative outcomes, including best-corrected visual acuity and the length of the disrupted external limiting membrane and ellipsoid zone, were compared. Preoperative features including visual acuity and hole size did not differ between the two groups. All studied eyes achieved closure of the macular hole postoperatively. Visual acuity significantly improved at 3, 6, and 12 months postoperatively in both groups. The visual acuity 1-month after surgery was better in the embedding group than that in the peeling group (0.28 ± 0.29 vs. 0.50 ± 0.42 logarithm of the minimum angle of resolution, P = 0.016), although the difference was not noted after 3 months postoperatively. The embedding group showed shorter disruption of the external limiting membrane than the peeling group postoperatively (62.6 ± 40.2 μm vs. 326.2 ± 463.9 μm at postoperative 12 months, P = 0.045). In conclusion, the embedding technique during surgical repair of a FTMH with EP facilitates recovery of the outer foveal layers and promotes earlier restoration of visual function.

为了比较患有全层黄斑裂孔 (FTMH) 和视网膜前增生 (EP) 的患者视网膜前增生剥离和嵌入的视觉和解剖结果，这项回顾性队列研究根据 EP 是否完全剥离将患者分为两组（剥离组） ，n = 25 只眼），或在手术过程中嵌入孔中（嵌入组，n = 31 只眼）。比较术前特征和术后结果，包括最佳矫正视力以及破坏的外界膜和椭球区的长度。两组的术前特征（包括视力和孔大小）没有差异。所有研究的眼睛术后黄斑裂孔均实现闭合。术后 3、6 和 12 个月，两组患者的视力均显着提高。术后1个月，埋植组的视力优于剥离组（0.28±0.29 vs. 0.50±0.42最小分辨角对数， P = 0.016），但3个月后差异不显着。术后几个月。埋置组术后外界膜破坏时间短于剥离组（术后12个月为62.6±40.2μm vs. 326.2±463.9μm， P =0.045）。总之，用 EP 进行 FTMH 手术修复时的埋置技术有助于外中心凹层的恢复，并促进视觉功能的早期恢复。