BACKGROUND:It is unknown whether maintaining normal blood pressure (BP) from middle to older age is associated with improved health outcomes.METHODS:We estimated the proportion of Atherosclerosis Risk in Communities study participants who maintained normal BP from 1987 to 1989 (visit 1) through 1996 to 1998 and 2011 to 2013 (over 4 and 5 visits, respectively). Normal BP was defined as systolic BP <120 mm Hg and diastolic BP <80 mm Hg, without antihypertensive medication. We estimated the risk of cardiovascular disease, dementia, and poor physical functioning after visit 5. In exploratory analyses, we examined participant characteristics associated with maintaining normal BP.RESULTS:Among 2699 participants with normal BP at baseline (mean age 51.3 years), 47.1% and 15.0% maintained normal BP through visits 4 and 5, respectively. The hazard ratios comparing participants who maintained normal BP through visit 4 but not visit 5 and through visit 5 versus those who did not maintain normal BP through visit 4 were 0.80 (95% CI, 0.63–1.03) and 0.60 (95% CI, 0.42–0.86), respectively, for cardiovascular disease, and 0.85 (95% CI, 0.71–1.01) and 0.69 (95% CI, 0.54–0.90), respectively, for poor physical functioning. Maintaining normal BP through visit 5 was more common among participants with normal body mass index versus obesity at visit 1, those with normal body mass index at visits 1 and 5, and those with overweight at visit 1 and overweight or normal body mass index at visit 5, compared with those with obesity at visits 1 and 5.CONCLUSIONS:Maintaining normal BP was associated with a lower risk of cardiovascular disease and poor physical functioning.

中文翻译：

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中老年维持正常血压：社区动脉粥样硬化风险研究的结果


背景：尚不清楚从中年到老年保持正常血压 (BP) 是否与改善健康结果相关。方法：我们估计了 1987 年至 1989 年间保持正常血压的社区研究参与者的动脉粥样硬化风险比例（访问 1） 1996年至1998年和2011年至2013年（分别超过4次和5次访问）。正常血压定义为收缩压<120毫米汞柱和舒张压<80毫米汞柱，无需服用抗高血压药物。我们评估了第 5 次访视后患心血管疾病、痴呆和身体功能不良的风险。在探索性分析中，我们检查了与维持正常血压相关的参与者特征。结果：在 2699 名基线血压正常的参与者中（平均年龄 51.3 岁），47.1 % 和 15.0% 分别通过第 4 次和第 5 次就诊保持正常血压。通过第 4 次就诊但未在第 5 次就诊和第 5 次就诊期间血压保持正常的参与者与在第 4 次就诊期间血压未保持正常的参与者的风险比分别为 0.80 (95% CI, 0.63–1.03) 和 0.60 (95% CI, 0.42)对于心血管疾病，分别为 0.85（95% CI，0.71-1.01）和 0.69（95% CI，0.54-0.90），对于身体机能较差。与访视 1 时体重指数正常的参与者相比，在访视 1 时体重指数正常的参与者、访视 1 时体重指数正常的参与者以及访视 1 时超重的参与者和访视时体重指数超重或正常的参与者中，通过访视 5 保持正常血压的情况更为常见5，与第 1 次和第 5 次就诊时肥胖的患者相比。结论：维持正常血压与较低的心血管疾病风险和较差的身体机能相关。