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Functional Near Infrared-Emitting Cr3+/Pr3+Co-Doped Zinc Gallogermanate Persistent Luminescent Nanoparticles with Superlong Afterglow forin VivoTargeted Bioimaging
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2013-09-17 , DOI: 10.1021/ja404243v Abdukader Abdukayum 1 , Jia-Tong Chen 1 , Qiang Zhao 1 , Xiu-Ping Yan 1
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2013-09-17 , DOI: 10.1021/ja404243v Abdukader Abdukayum 1 , Jia-Tong Chen 1 , Qiang Zhao 1 , Xiu-Ping Yan 1
Affiliation
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Near infrared (NIR)-emitting persistent luminescent nanoparticles (PLNPs) have great potential for in vivo bioimaging with the advantages of no need for in situ excitation, high signal-to-noise ratio, and deep tissue penetration. However, functional NIR-emitting PLNPs with long afterglow for long-term in vivo imaging are lacking. Here, we show the synthesis of NIR-emitting long-persistent luminescent nanoparticles (LPLNPs) Zn2.94Ga1.96Ge2O10:Cr(3+),Pr(3+) by a citrate sol-gel method in combination with a subsequent reducing atmosphere-free calcination. The persistent luminescence of the LPLNPs is significantly improved via codoping Pr(3+)/Cr(3+) and creating suitable Zn deficiency in zinc gallogermanate. The LPLNP powder exhibits bright NIR luminescence in the biological transparency window with a superlong afterglow time of over 15 days. A persistent energy transfer between host and Cr(3+) ion in the LPLNPs is observed and its mechanism is discussed. PEGylation greatly improves the biocompatibility and water solubility of the LPLNPs. Further bioconjugation with c(RGDyK) peptide makes the LPLNPs promising for long-term in vivo targeted tumor imaging with low toxicity.
中文翻译：
用于体内靶向生物成像的具有超长余辉的功能性近红外发射 Cr3+/Pr3+ 共掺杂锌镓锗持久发光纳米颗粒
近红外 (NIR) 发射持久发光纳米粒子 (PLNPs) 具有无需原位激发、高信噪比和深层组织穿透等优点，在体内生物成像方面具有巨大潜力。然而，缺乏用于长期体内成像的具有长余辉的功能性 NIR 发射 PLNP。在这里，我们展示了通过柠檬酸盐溶胶-凝胶法结合随后的还原气氛合成 NIR 发射长余辉发光纳米粒子 (LPLNPs) Zn2.94Ga1.96Ge2O10:Cr(3+),Pr(3+) -自由煅烧。LPLNPs 的持续发光通过共掺杂 Pr(3+)/Cr(3+) 和在镓锗酸锌中产生合适的锌缺乏而得到显着改善。LPLNP 粉末在生物透明窗口中表现出明亮的近红外发光，超长余辉时间超过 15 天。观察到 LPLNPs 中宿主和 Cr(3+) 离子之间的持久能量转移并讨论其机制。聚乙二醇化极大地提高了 LPLNPs 的生物相容性和水溶性。与 c(RGDyK) 肽的进一步生物偶联使 LPLNPs 有望用于低毒性的长期体内靶向肿瘤成像。
更新日期：2013-09-17
中文翻译：
用于体内靶向生物成像的具有超长余辉的功能性近红外发射 Cr3+/Pr3+ 共掺杂锌镓锗持久发光纳米颗粒
近红外 (NIR) 发射持久发光纳米粒子 (PLNPs) 具有无需原位激发、高信噪比和深层组织穿透等优点，在体内生物成像方面具有巨大潜力。然而，缺乏用于长期体内成像的具有长余辉的功能性 NIR 发射 PLNP。在这里，我们展示了通过柠檬酸盐溶胶-凝胶法结合随后的还原气氛合成 NIR 发射长余辉发光纳米粒子 (LPLNPs) Zn2.94Ga1.96Ge2O10:Cr(3+),Pr(3+) -自由煅烧。LPLNPs 的持续发光通过共掺杂 Pr(3+)/Cr(3+) 和在镓锗酸锌中产生合适的锌缺乏而得到显着改善。LPLNP 粉末在生物透明窗口中表现出明亮的近红外发光，超长余辉时间超过 15 天。观察到 LPLNPs 中宿主和 Cr(3+) 离子之间的持久能量转移并讨论其机制。聚乙二醇化极大地提高了 LPLNPs 的生物相容性和水溶性。与 c(RGDyK) 肽的进一步生物偶联使 LPLNPs 有望用于低毒性的长期体内靶向肿瘤成像。
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