Gut microbiome differences between people with Parkinson’s disease (PD) and control subjects without Parkinsonism are widely reported, but potential alterations related to PD with mild cognitive impairment (MCI) have yet to be comprehensively explored. We compared gut microbial features of PD with MCI (n = 58) to cognitively unimpaired PD (n = 60) and control subjects (n = 90) with normal cognition. Our results did not support a specific microbiome signature related to MCI in PD.

中文翻译：

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肠道微生物群与帕金森病的轻度认知障碍无关

帕金森病 (PD) 患者与非帕金森病对照受试者之间的肠道微生物组差异已被广泛报道，但与轻度认知障碍 (MCI) 的帕金森病相关的潜在改变尚未得到全面探索。我们将患有 MCI 的 PD 的肠道微生物特征 ( n = 58) 与认知未受损的 PD ( n = 60) 和认知正常的对照受试者 ( n = 90) 进行了比较。我们的结果不支持与 PD 中 MCI 相关的特定微生物组特征。