Chronic trans fatty acid consumption shortens lifespan in male Drosophila melanogaster on a high-sugar and high-fat diet,Biogerontology

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Chronic trans fatty acid consumption shortens lifespan in male Drosophila melanogaster on a high-sugar and high-fat diet
Biogerontology ( IF 4.4 ) Pub Date : 2024-04-06 , DOI: 10.1007/s10522-024-10101-1
Qianhua Yuan ₁ , Mengliu Luo ₁ , Yutong Xie ₁ , Wanhan Song ₁ , Ya Wang ₁ , Dazhang Deng ₁ , Shuyan Chen ₁ , Honghui Guo _{1,

2}

Affiliation

Aging entails the progressive decline in the body’s self-regulation and functionality over time. Notably, obesity and aging exhibit parallel phenotypes, with obesity further accelerating the aging process across multiple dimensions and diminishing lifespan. In this study, we explored the impact of trans fatty acid (TFA) consumption on the overall health and lifespan of male Drosophila melanogaster under an isocaloric high-sugar and high-fat diet. Our results indicate that TFA intake results in a shortened lifespan, elevated body weight, and increased triglyceride levels in flies fed a high-sugar and high-fat diet with equivalent caloric intake. Additionally, TFA exposure induces oxidative stress, locomotor deficits, and damage to the intestinal barrier in flies. Collectively, chronic TFA consumption expedites the aging process and reduces the lifespan of male Drosophila melanogaster. These results contribute supplementary evidence regarding the adverse health effects associated with TFAs.

Graphical Abstract

Trans fatty acid intake results in a shortened lifespan, elevated body weight, and increased triglyceride levels in male Drosophila melanogaster fed a high-sugar and high-fat diet with equivalent caloric intake. Additionally, Trans fatty acid exposure induces oxidative stress, locomotor deficits, and damage to the intestinal barrier in flies.

中文翻译：

长期摄入反式脂肪酸会缩短高糖和高脂肪饮食的雄性黑腹果蝇的寿命

衰老会导致身体的自我调节和功能随着时间的推移而逐渐下降。值得注意的是，肥胖和衰老表现出平行的表型，肥胖在多个维度上进一步加速衰老过程并缩短寿命。在这项研究中，我们探讨了在等热量高糖和高脂肪饮食下，反式脂肪酸（TFA）消费对雄性黑腹果蝇整体健康和寿命的影响。我们的结果表明，摄入 TFA 会导致喂食高糖和高脂肪饮食且热量摄入相等的果蝇寿命缩短、体重升高和甘油三酯水平升高。此外，TFA 暴露会诱导果蝇的氧化应激、运动缺陷和肠道屏障损伤。总的来说，长期食用 TFA 会加速衰老过程并缩短雄性黑腹果蝇的寿命。这些结果为与 TFA 相关的不良健康影响提供了补充证据。