Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Cardiopulmonary Bypass.,Critical Care Medicine

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Anaerobic Lactate Production Is Associated With Decreased Microcirculatory Blood Flow and Decreased Mitochondrial Respiration Following Cardiovascular Surgery With Cardiopulmonary Bypass.
Critical Care Medicine ( IF 7.7 ) Pub Date : 2024-04-05 , DOI: 10.1097/ccm.0000000000006289
John C Greenwood _{1,

2} , Fatima M Talebi ₁ , David H Jang ₁ , Audrey E Spelde ₂ , Emily K Gordon ₂ , Jiri Horak ₂ , Michael A Acker ₃ , Todd J Kilbaugh ₄ , Frances S Shofer ₅ , John G T Augoustides ₂ , Jacob S Brenner ₆ , Vladimir R Muzykantov ₇ , Jan Bakker ₈ , Benjamin S Abella _{1,

2}

Affiliation

Department of Emergency Medicine, Center for Resuscitation Science, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Division of Cardiovascular Surgery, Department of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Department of Anesthesiology and Critical Care Medicine, Center for Mitochondrial and Epigenomic Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA.
Department of Epidemiology & Biostatistics, Department of Emergency Medicine Hospital of the University of Pennsylvania, Philadelphia, PA.
Division of Pulmonary, Allergy, & Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Department of Pharmacology and Center for Translational Targeted Therapeutics and Nanomedicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Department of Intensive Care Adults, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Quantify the relationship between perioperative anaerobic lactate production, microcirculatory blood flow, and mitochondrial respiration in patients after cardiovascular surgery with cardiopulmonary bypass.

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