Objectives To get a better understanding of the scientific values of flavone scutellarein (SCT), and to encourage its applications in human health, the current review systematically summarizes the natural observation, biosynthesis, synthesis, pharmacology, pharmacokinetics, and recent synthetic advances Key findings Scientific sources to search for references included Google Scholar, Scopus, Web of Science, PubMed, Sci-Finder, and journal websites. The references have been collected from the 1970s to the present. “Scutellarein” is the most meaningful keyword to search for publications, in which it was used alone or in combination with other keywords. Summarys SCT as a hydrophobic flavonoid can be found in various medicinal plants of the families Lamiaceae, Compositae, and Verbenaceae. Flavone SCT has drawn much interest due to its wide pharmacological effects, such as anticancer, anti-inflammation, antioxidant, antiobesity, and vasorelaxant. The SCT treatments also possessed a lot of positive results in the neuron, liver, heart, lung, kidney, bone, and skin protective experiments, and human sperm function enhancement. Its underlying mechanism of action may relate to the apoptotic program and cytokine inhibition by regulating a panel of the signaling pathway, e.g., NF-κB (nuclear factor kappa B)/MAPK (mitogen-activated protein kinase), IκBa (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitors alpha)/NF-κB, TRAF2 (tumor necrosis factor receptor-associated factor 2)/NF-κB, and PTEN (phosphatase and tension homologue deleted on chromosome 10)/Akt (protein kinase B)/NF-κB. In addition, the metabolic actions and synthetic derivative promotions of SCT were mostly based on the substitution of hydroxyl groups. Collectively, the studies that aim to highlight the role of scutellarein in preclinical and clinical treatments are urgently needed. More and more experiments to improve its bioavailability are expected.

中文翻译：

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黄芩素：化学和药理学综述


目的 为了更好地了解黄酮黄芩素（SCT）的科学价值，并鼓励其在人类健康中的应用，本综述系统总结了黄酮黄酮黄芩素（SCT）的自然观察、生物合成、合成、药理学、药代动力学和最新合成进展。搜索参考文献的来源包括 Google Scholar、Scopus、Web of Science、PubMed、Sci-Finder 和期刊网站。参考文献是从 20 世纪 70 年代至今收集的。 “Scutellarein”是搜索出版物时最有意义的关键词，它可以单独使用或与其他关键词结合使用。摘要 SCT 作为一种疏水性黄酮类化合物，存在于唇形科、菊科和马鞭草科的各种药用植物中。黄酮SCT因其广泛的药理作用而引起广泛关注，如抗癌、抗炎、抗氧化、抗肥胖和血管舒张等。 SCT治疗在神经元、肝脏、心脏、肺、肾、骨骼和皮肤保护实验以及人类精子功能增强方面也取得了很多积极的成果。其潜在作用机制可能与通过调节一组信号通路来抑制细胞凋亡和细胞因子抑制有关，例如NF-κB（核因子κB）/MAPK（丝裂原激活蛋白激酶）、IκBa（核因子κB） B 细胞中的轻多肽基因增强子抑制剂 α)/NF-κB、TRAF2（肿瘤坏死因子受体相关因子 2）/NF-κB 和 PTEN（10 号染色体上删除的磷酸酶和张力同源物）/Akt（蛋白激酶 B） /NF-κB。此外，SCT的代谢作用和合成衍生物的促进作用大多基于羟基的取代。 总的来说，迫切需要旨在强调灯盏花素在临床前和临床治疗中的作用的研究。预计会有越来越多的实验来提高其生物利用度。