A CuI6L4 Cage Dynamically Reconfigures to Form Suit[4]anes and Selectively Bind Fluorinated Steroids,Journal of the American Chemical Society

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A CuI6L4 Cage Dynamically Reconfigures to Form Suit[4]anes and Selectively Bind Fluorinated Steroids
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2024-04-05 , DOI: 10.1021/jacs.4c00257
Natasha M A Speakman ₁ , Andrew W Heard _{1,

2} , Jonathan R Nitschke ₁

Affiliation

Simple organic ligands can self-assemble with metal ions to generate metal–organic cages, whose cavities bind guests selectively. This binding may enable new methods of chemical separation or sensing, among other useful functions. Here we report the preparation of a Cu^I₆L₄ pseudo-octahedral metal–organic cage, the ligands of which self-assemble from simple organic building blocks. Temperature, solvent, and the presence of different guests governed which structure predominated from a dynamic mixture of cage diastereomers with different arrangements of right- or left-handed metal vertices. Dissolution in dimethyl sulfoxide or the binding of tetrahedral guests led to a chiral tetrahedral T-symmetric framework, whereas low temperatures favored the achiral S₄-symmetric diastereomer. Tetrahedral guests with long arms were encapsulated to form mechanically bonded suit[4]anes, with guest arms protruding out through host windows. The cage was also observed to bind fluorinated steroids, an important class of drug molecules, but not non-fluorinated steroids, providing the basis for new separation processes.

中文翻译：

CuI6L4 笼动态重新配置以形成合适[4]烷并选择性结合氟化类固醇

简单的有机配体可以与金属离子自组装形成金属有机笼，其空腔选择性地结合客体。这种结合可以实现化学分离或传感的新方法以及其他有用的功能。在这里，我们报道了 Cu ^I ₆ L ₄伪八面体金属有机笼的制备，其配体由简单的有机构件自组装而成。温度、溶剂和不同客体的存在决定了由具有不同右旋或左旋金属顶点排列的笼形非对映异构体动态混合物构成的结构。在二甲亚砜中的溶解或四面体客体的结合产生了手性四面体T对称框架，而低温有利于非手性S ₄对称非对映异构体。具有长臂的四面体客人被封装成机械粘合的套房[4]，客人的手臂从主人的窗户伸出。还观察到该笼能够结合氟化类固醇（一类重要的药物分子），但不结合非氟化类固醇，这为新的分离过程提供了基础。

更新日期：2024-04-05

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