Summary: Cancer is traditionally perceived through a genetic lens, with therapeutic strategies targeting oncogenic driver mutations. We advocate an overarching framework recognizing tumors as comprising driver, passenger, and trailer cell states: Tailoring therapies to simultaneously target driver genetics and cell states may enhance effectiveness and durability.

中文翻译：

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癌症中的细胞状态：司机、乘客和拖车


摘要：传统上通过遗传视角来看待癌症，并采用针对致癌驱动突变的治疗策略。我们主张建立一个总体框架，将肿瘤视为由驱动细胞、乘客细胞和尾部细胞状态组成：同时针对驱动基因和细胞状态的定制疗法可能会提高有效性和持久性。