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Photopolymerized Multifunctional Hydrogel Loaded with Asiaticoside and Growth Factor for Accelerating Diabetic Wound Healing
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2024-04-01 , DOI: 10.1021/acsapm.4c00381 Zhen Wang 1 , Fangzheng Zhao 1 , Junxia Deng 1 , Huijuan Song 2 , Feifei Ma 2 , Ligong Chen 1 , Weiwei Wang 3 , Jinfeng Xing 1
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2024-04-01 , DOI: 10.1021/acsapm.4c00381 Zhen Wang 1 , Fangzheng Zhao 1 , Junxia Deng 1 , Huijuan Song 2 , Feifei Ma 2 , Ligong Chen 1 , Weiwei Wang 3 , Jinfeng Xing 1
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Diabetic wounds are difficult to heal for a long time because of their complex bacterial infection, excessive inflammation, and angiogenesis obstruction. An effective treatment strategy is desirable to accelerate diabetic wound healing. Herein, a highly adhesive, stretchable, self-healing, and antibacterial multifunctional hydrogel loaded with asiaticoside (AS) and recombinant basic human fibroblast growth factor 2 (FGF-2) in situ is rapidly prepared by photopolymerization under green light-emitting diode (LED) irradiation within 80 s. The hydrogel exhibits high stretchability, outstanding tissue adhesive properties, and good self-healing properties. Moreover, the hydrogel exhibits excellent biocompatibility, enhanced cell proliferation and migration ability, and broad-spectrum antibacterial activity. The hydrogel can effectively modulate the continuous release of AS and FGF-2 to enhance the antibacterial, anti-inflammatory, and angiogenesis effects to synergistically accelerate diabetic wound healing. Notably, the hydrogel can effectively enhance the ability to promote angiogenesis and collagen deposition and significantly shorten the healing time of diabetic wound in rats. Therefore, it is an effective strategy to prepare a multifunctional hydrogel loaded with AS and FGF-2 by photopolymerization under green LED irradiation for accelerating diabetic wound healing.
中文翻译：
负载积雪草苷和生长因子的光聚合多功能水凝胶可加速糖尿病伤口愈合
糖尿病伤口由于细菌感染复杂、炎症过度、血管生成受阻等原因，难以长期愈合。需要有效的治疗策略来加速糖尿病伤口愈合。在此，通过在绿光发光二极管（LED）下光聚合快速制备了原位负载积雪草苷（AS）和重组碱性人成纤维细胞生长因子2（FGF-2）的高粘附性、可拉伸、自修复和抗菌多功能水凝胶。 ）80秒内照射。该水凝胶具有高拉伸性、出色的组织粘合性能和良好的自修复性能。此外，该水凝胶具有优异的生物相容性、增强的细胞增殖和迁移能力以及广谱抗菌活性。该水凝胶可以有效调节AS和FGF-2的持续释放，增强抗菌、抗炎和血管生成作用，协同加速糖尿病伤口愈合。值得注意的是，该水凝胶可以有效增强促进血管生成和胶原沉积的能力，并显着缩短大鼠糖尿病伤口的愈合时间。因此，在绿色LED照射下通过光聚合制备负载AS和FGF-2的多功能水凝胶是加速糖尿病伤口愈合的有效策略。
更新日期：2024-04-01
中文翻译：
负载积雪草苷和生长因子的光聚合多功能水凝胶可加速糖尿病伤口愈合
糖尿病伤口由于细菌感染复杂、炎症过度、血管生成受阻等原因，难以长期愈合。需要有效的治疗策略来加速糖尿病伤口愈合。在此，通过在绿光发光二极管（LED）下光聚合快速制备了原位负载积雪草苷（AS）和重组碱性人成纤维细胞生长因子2（FGF-2）的高粘附性、可拉伸、自修复和抗菌多功能水凝胶。 ）80秒内照射。该水凝胶具有高拉伸性、出色的组织粘合性能和良好的自修复性能。此外，该水凝胶具有优异的生物相容性、增强的细胞增殖和迁移能力以及广谱抗菌活性。该水凝胶可以有效调节AS和FGF-2的持续释放，增强抗菌、抗炎和血管生成作用，协同加速糖尿病伤口愈合。值得注意的是，该水凝胶可以有效增强促进血管生成和胶原沉积的能力，并显着缩短大鼠糖尿病伤口的愈合时间。因此，在绿色LED照射下通过光聚合制备负载AS和FGF-2的多功能水凝胶是加速糖尿病伤口愈合的有效策略。
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