The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of the organism. Among its various forms, skeletal interoception specifically regulates the metabolic homeostasis of bones. Osteoarthritis (OA) is a complex joint disorder involving cartilage, subchondral bone, and synovium. The subchondral bone undergoes continuous remodeling to adapt to dynamic joint loads. Recent findings highlight that skeletal interoception mediated by aberrant mechanical loads contributes to pathological remodeling of the subchondral bone, resulting in subchondral bone sclerosis in OA. The skeletal interoception is also a potential mechanism for chronic synovial inflammation in OA. In this review, we offer a general overview of interoception, specifically skeletal interoception, subchondral bone microenviroment and the aberrant subchondral remedeling. We also discuss the role of skeletal interoception in abnormal subchondral bone remodeling and synovial inflammation in OA, as well as the potential prospects and challenges in exploring novel OA therapies that target skeletal interoception.

内感受在感知有机体内部状态的变化后通过释放调节信号来维持适当的生理条件和代谢稳态。在其各种形式中，骨骼内感受专门调节骨骼的代谢稳态。骨关节炎 (OA) 是一种复杂的关节疾病，涉及软骨、软骨下骨和滑膜。软骨下骨经历持续重塑以适应动态关节负荷。最近的研究结果强调，异常机械负荷介导的骨骼内感受有助于软骨下骨的病理重塑，导致 OA 软骨下骨硬化。骨骼内感受也是 OA 慢性滑膜炎症的潜在机制。在这篇综述中，我们对内感受进行了总体概述，特别是骨骼内感受、软骨下骨微环境和异常的软骨下重塑。我们还讨论了骨骼内感受在 OA 异常软骨下骨重塑和滑膜炎症中的作用，以及探索针对骨骼内感受的新型 OA 疗法的潜在前景和挑战。