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Chitin: A versatile biopolymer-based functional therapy for cartilage regeneration
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2024-03-23 , DOI: 10.1016/j.ijbiomac.2024.131120 Huma Hameed 1 , Mahtab Ahmad Khan 1 , Ana Cláudia Paiva-Santos 2 , Nelofer Ereej 1 , Saleha Faheem 1
International Journal of Biological Macromolecules ( IF 7.7 ) Pub Date : 2024-03-23 , DOI: 10.1016/j.ijbiomac.2024.131120 Huma Hameed 1 , Mahtab Ahmad Khan 1 , Ana Cláudia Paiva-Santos 2 , Nelofer Ereej 1 , Saleha Faheem 1
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Chitin is the second most abundant biopolymer and its inherent biological characteristics make it ideal to use for tissue engineering. For many decades, its properties like non-toxicity, abundant availability, ease of modification, biodegradability, biocompatibility, and anti-microbial activity have made chitin an ideal biopolymer for drug delivery. Research studies have also shown many potential benefits of chitin in the formulation of functional therapy for cartilage regeneration. Chitin and its derivatives can be processed into 2D/3D scaffolds, hydrogels, films, exosomes, and nano-fibers, which make it a versatile and functional biopolymer in tissue engineering. Chitin is a biomimetic polymer that provides targeted delivery of mesenchymal stem cells, especially of chondrocytes at the injected donor sites to accelerate regeneration by enhancing cell proliferation and differentiation. Due to this property, chitin is considered an interesting polymer that has a high potential to provide targeted therapy in the regeneration of cartilage. Our paper presents an overview of the method of extraction, structure, properties, and functional role of this versatile biopolymer in tissue engineering, especially cartilage regeneration.
中文翻译：
甲壳素：一种基于生物聚合物的多功能软骨再生功能疗法
甲壳素是第二丰富的生物聚合物，其固有的生物学特性使其非常适合用于组织工程。几十年来，其无毒性、丰富的可用性、易于修饰、生物降解性、生物相容性和抗菌活性等特性使甲壳素成为药物输送的理想生物聚合物。研究还表明，甲壳素在软骨再生功能疗法的制定中具有许多潜在的益处。甲壳素及其衍生物可以加工成2D/3D支架、水凝胶、薄膜、外泌体和纳米纤维，这使其成为组织工程中的多功能和功能性生物聚合物。甲壳质是一种仿生聚合物，可靶向递送间充质干细胞，特别是注射供体部位的软骨细胞，通过增强细胞增殖和分化来加速再生。由于这种特性，甲壳素被认为是一种有趣的聚合物，在软骨再生方面具有提供靶向治疗的巨大潜力。我们的论文概述了这种多功能生物聚合物在组织工程，特别是软骨再生中的提取方法、结构、性质和功能作用。
更新日期：2024-03-23
中文翻译：
甲壳素：一种基于生物聚合物的多功能软骨再生功能疗法
甲壳素是第二丰富的生物聚合物，其固有的生物学特性使其非常适合用于组织工程。几十年来，其无毒性、丰富的可用性、易于修饰、生物降解性、生物相容性和抗菌活性等特性使甲壳素成为药物输送的理想生物聚合物。研究还表明，甲壳素在软骨再生功能疗法的制定中具有许多潜在的益处。甲壳素及其衍生物可以加工成2D/3D支架、水凝胶、薄膜、外泌体和纳米纤维，这使其成为组织工程中的多功能和功能性生物聚合物。甲壳质是一种仿生聚合物，可靶向递送间充质干细胞，特别是注射供体部位的软骨细胞，通过增强细胞增殖和分化来加速再生。由于这种特性，甲壳素被认为是一种有趣的聚合物，在软骨再生方面具有提供靶向治疗的巨大潜力。我们的论文概述了这种多功能生物聚合物在组织工程，特别是软骨再生中的提取方法、结构、性质和功能作用。
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