trans-2-(Trifluoromethyl)cyclopropylboronic acid N-methyliminodiacetic acid (MIDA) ester 5 was synthesized as a pure diastereomer from vinylboronic acid MIDA ester and (trifluoromethyl)diazomethane in a single step. An X-ray study confirmed the trans-stereochemistry around the cyclopropyl ring. Use of 5 in Suzuki reactions, with a variety of aryl or heteroaryl coupling partners, provided trans-2-(trifluoromethyl)cyclopropyl products in moderate to excellent yields (17–90%).

中文翻译：

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N-甲基亚氨基二乙酸硼酸酯的Suzuki反应合成反式-2-（三氟甲基）环丙烷

反式-2-（三氟甲基）环丙基硼酸Ñ -methyliminodiacetic乙酸（MIDA）酯5的合成从乙烯基硼酸MIDA酯和（三氟甲基）重氮甲烷在单个步骤中的纯非对映体。X射线研究证实了环丙基环周围的反式立体化学。在Suzuki反应中使用5和各种芳基或杂芳基偶合伙伴，可提供中等至极好的收率（17-90％）的反式-2-（三氟甲基）环丙基产品。