Pain control after deep brain stimulation (DBS) in Parkinson’s disease (PD) remains unclear. Following six months, subthalamic (STN)-DBS reduced sensory complaints related to parkinsonism and bodily discomfort, increasing central beta-endorphin level. Pallidal GPi-DBS decreased bodily discomfort and beta-endorphin levels. Unexplained pain by other conditions and bodily discomfort were negatively correlated with beta-endorphin levels. Thus, DBS regulates central opioids, and prioritizing STN is important for PD patients with significant sensory complications.

中文翻译：

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丘脑底核与苍白球内部深部脑刺激对感觉不适的疗效

帕金森病 (PD) 患者深部脑刺激 (DBS) 后的疼痛控制仍不清楚。六个月后，丘脑底 (STN)-DBS 减少了与帕金森症和身体不适相关的感觉不适，增加了中枢 β-内啡肽水平。苍白球 GPi-DBS 降低了身体不适和 β-内啡肽水平。其他原因引起的不明原因疼痛和身体不适与β-内啡肽水平呈负相关。因此，DBS 调节中枢阿片类药物，优先考虑 STN 对于有明显感觉并发症的 PD 患者很重要。