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Clinical Efficacy of Beta-1 Selective Beta-Blockers Versus Propranolol in Patients With Thyroid Storm: A Retrospective Cohort Study.
Critical Care Medicine ( IF 7.7 ) Pub Date : 2024-03-29 , DOI: 10.1097/ccm.0000000000006285
Yuichiro Matsuo 1 , Taisuke Jo 2 , Hideaki Watanabe 1 , Hiroki Matsui 1 , Kiyohide Fushimi 3 , Hideo Yasunaga 1
Affiliation  

Thyroid storm is the most severe manifestation of thyrotoxicosis. Beta-blockers are among the standard treatment regimens for this condition, with propranolol being the historically preferred option. However, 2016 guidelines issued by the Japan Thyroid Association and the Japan Endocrine Society recommend the use of beta-1 selective beta-blockers over nonselective beta-blockers, such as propranolol. Nevertheless, evidence supporting this recommendation is limited. Herein, we aimed to investigate the in-hospital mortality of patients with thyroid storms based on the choice of beta-blockers.

中文翻译:


Beta-1 选择性 β 受体阻滞剂与普萘洛尔对甲状腺危象患者的临床疗效:一项回顾性队列研究。



甲状腺危象是甲状腺毒症最严重的表现。 β-受体阻滞剂是这种情况的标准治疗方案之一,普萘洛尔是历史上的首选选择。然而,日本甲状腺协会和日本内分泌学会发布的 2016 年指南建议使用 β-1 选择性 β 受体阻滞剂,而不是普萘洛尔等非选择性 β 受体阻滞剂。然而,支持这一建议的证据有限。在此,我们旨在根据β受体阻滞剂的选择调查甲状腺危象患者的院内死亡率。
更新日期:2024-03-29
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