The steroidal plant growth-promoting lactone epocholeone has attracted much attention due to its great potential applications in agriculture. Herein, we report a chromatography–free synthesis of the epocholeone using a potassium osmate-catalyzed asymmetric dihydroxylation as the key reaction. Compared to the existing literature routes, the current protocol features low–toxicity reagents, simple operations and mild conditions. We expect this practical synthesis offers a preferred means to produce epocholeone in manufacturing.

中文翻译：

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长效植物促生长类固醇epocholeone的实际合成

甾体植物促生长内酯epocholeone因其在农业中的巨大应用潜力而备受关注。在此，我们报告了一种使用锇酸钾催化的不对称二羟基化作为关键反应的埃波胆酮的无色谱合成。与现有文献路线相比，本方案具有试剂低毒、操作简单、条件温和的特点。我们期望这种实用的合成提供了在制造中生产 Epocholeone 的首选方法。