Monitoring ROS Responsive Fe3O4-based Nanoparticle Mediated Ferroptosis and Immunotherapy via 129Xe MRI,Angewandte Chemie International Edition

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Monitoring ROS Responsive Fe3O4-based Nanoparticle Mediated Ferroptosis and Immunotherapy via 129Xe MRI
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2024-03-29 , DOI: 10.1002/anie.202403771
Lei Zhang _{1,

2} , Maosong Qiu _{1,

2} , Ruifang Wang _{1,

2} , Sha Li _{1,

2} , Xiaoxun Liu _{1,

2} , Qiuyi Xu _{1,

2} , Long Xiao _{1,

2} , Zhong-Xing Jiang _{1,

2} , Xin Zhou _{1,

2,

3} , Shizhen Chen _{1,

2,

3}

Affiliation

A self-supplying ROS-responsive Fe₃O₄ nanoparticle was designed to enhance the therapeutic efficacy of ferroptosis and immunotherapy by ROS-mediated size reduction and charge reversion. Moreover, the ¹²⁹Xe MRI of lung metastases showed significant differences in lung ventilation defects in the treatment and control groups, indicating the great potential of ¹²⁹Xe MRI for monitoring the immunotherapeutic efficacy of lung metastatic cancer.

中文翻译：

通过 129Xe MRI 监测 ROS 响应性 Fe3O4 纳米颗粒介导的铁死亡和免疫治疗

设计了一种自供给ROS响应性Fe ₃ O ₄纳米粒子，通过ROS介导的尺寸减小和电荷反转来增强铁死亡和免疫疗法的治疗效果。此外，肺转移瘤的¹²⁹ Xe MRI 显示治疗组和对照组的肺通气缺陷存在显着差异，表明¹²⁹ Xe MRI 在监测肺转移癌免疫治疗效果方面具有巨大潜力。

更新日期：2024-03-29

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