The recent study by Djinbachian et al comparing accuracy of intracolonoscopic to pathology-based assessment of colorectal polyp size is of considerable interest.1 The authors reported that pathology sizing is often not possible because of piecemeal polyp resection or fragmentation during retrieval and, for intact polypectomy specimens, pathology accuracy is limited by formalin-related shrinkage. 78% of pathology-based polyp measurements were smaller than the reference postcolonoscopy size assessed by digital vernier calipre, and mean shrinkage effect was estimated at 25.7%. However, there is another aspect of the pathology assessment which has not been considered and is perhaps a more likely explanation of size reduction based on pathology measurement. While formalin-related specimen shrinkage is well established, this mainly relates to specimens with significant contractility, such as cutaneous specimens.2 Studies examining the impact of formalin on polyp sizing have yielded conflicting results, though most have suggested …

中文翻译：

---

结直肠息肉大小的显微镜病理学评估不如结肠镜评估准确


Djinbachian 等人最近的研究将结肠内镜检查的准确性与基于病理学的结直肠息肉大小评估进行了比较，这引起了相当大的兴趣。作者报告说，由于取回过程中息肉的零碎切除或碎裂，通常无法进行病理学大小测定，并且对于完整的息肉切除术标本，病理学准确性受到福尔马林相关收缩的限制。78% 的基于病理学的息肉测量值小于数字游标卡尺评估的参考结肠镜后大小，平均收缩效应估计为 25.7%。然而，病理学评估的另一个方面尚未被考虑，也许是基于病理测量的尺寸缩小的更可能的解释。虽然福尔马林相关的标本收缩已得到充分证实，但这主要与具有显着收缩力的标本有关，例如皮肤标本.2 检查福尔马林对息肉大小影响的研究得出了相互矛盾的结果，尽管大多数人认为......