Cucurbituril-Based Porphyrin Cascade Assembly for Cell Imaging and Targeted Drug Delivery,ACS Applied Polymer Materials

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Cucurbituril-Based Porphyrin Cascade Assembly for Cell Imaging and Targeted Drug Delivery
ACS Applied Polymer Materials ( IF 4.4 ) Pub Date : 2024-03-29 , DOI: 10.1021/acsapm.4c00571
Xing Yuan ₁ , De-Fang Xu ₂ , Yahui Song ₁ , Ying-Ming Zhang ₁ , Yu Liu ₁

Affiliation

Supramolecular assemblies based on multiple host–guest interactions have aroused widespread interest in the fabrication of innovative biomaterials. In this work, a combinational nanosupramolecule is constructed by an orthogonal two-step self-assembling process. The generation efficiency of reactive oxygen species and fluorescence emission intensity of pyridinium-appended porphyrin are greatly enhanced upon inclusion complexation with cucurbit[8]uril. Meanwhile, the introduction of β-cyclodextrin-grafted hyaluronic acid can facilitate the formation of secondary assemblies and endow them with the desired targeting ability toward cancer cells. After carrying doxorubicin hydrochloride as the loaded cargo, the resultant supramolecular nanoparticles exhibit much higher anticancer activity at the cellular level upon the near-infrared light irradiation. To be envisioned, such nanosupramolecular assemblies featuring both advantageous photodynamic and chemotherapeutic effects may be developed as more promising nanoplatforms for disease diagnosis and treatment.

中文翻译：

用于细胞成像和靶向药物输送的基于葫芦脲的卟啉级联组装

基于多种主客体相互作用的超分子组装体引起了人们对创新生物材料制造的广泛兴趣。在这项工作中，通过正交两步自组装过程构建了组合纳米超分子。吡啶鎓卟啉与葫芦[8]脲包合后，活性氧的产生效率和荧光发射强度大大提高。同时，β-环糊精接枝透明质酸的引入可以促进二次组装体的形成，并赋予其对癌细胞所需的靶向能力。以盐酸阿霉素为负载物后，所得超分子纳米粒子在近红外光照射下在细胞水平上表现出更高的抗癌活性。可以预见，这种具有有利的光动力和化疗效应的纳米超分子组装体可能会被开发为更有前景的疾病诊断和治疗纳米平台。

更新日期：2024-03-29

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