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A structure-functionality insight into the bioactivity of microbial polysaccharides toward biomedical applications: A review
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2024-03-21 , DOI: 10.1016/j.carbpol.2024.122078
Hongxing Zhang 1 , Yan Li 1 , Yinyi Fu 2 , Haixin Jiao 1 , Xiangyu Wang 1 , Qianqian Wang 1 , Mengbo Zhou 1 , Yang-Chun Yong 2 , Jun Liu 2
Carbohydrate Polymers ( IF 10.7 ) Pub Date : 2024-03-21 , DOI: 10.1016/j.carbpol.2024.122078
Hongxing Zhang 1 , Yan Li 1 , Yinyi Fu 2 , Haixin Jiao 1 , Xiangyu Wang 1 , Qianqian Wang 1 , Mengbo Zhou 1 , Yang-Chun Yong 2 , Jun Liu 2
Affiliation
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Microbial polysaccharides (MPs) are biopolymers secreted by microorganisms such as bacteria and fungi during their metabolic processes. Compared to polysaccharides derived from plants and animals, MPs have advantages such as wide sources, high production efficiency, and less susceptibility to natural environmental influences. The most attractive feature of MPs lies in their diverse biological activities, such as antioxidative, anti-tumor, antibacterial, and immunomodulatory activities, which have demonstrated immense potential for applications in functional foods, cosmetics, and biomedicine. These bioactivities are precisely regulated by their sophisticated molecular structure. However, the mechanisms underlying this precise regulation are not yet fully understood and continue to evolve. This article presents a comprehensive review of the most representative species of MPs, including their fermentation and purification processes and their biomedical applications in recent years. In particular, this work presents an in-depth analysis into the structure-activity relationships of MPs across multiple molecular levels. Additionally, this review discusses the challenges and prospects of investigating the structure-activity relationships, providing valuable insights into the broad and high-value utilization of MPs.
中文翻译：
微生物多糖生物活性的结构-功能洞察在生物医学应用中的应用：综述
微生物多糖（MPs）是细菌、真菌等微生物在代谢过程中分泌的生物聚合物。与动植物多糖相比，MPs具有来源广、生产效率高、不易受自然环境影响等优点。 MP最吸引人的特点在于其多样化的生物活性，如抗氧化、抗肿瘤、抗菌和免疫调节活性，这些活性在功能性食品、化妆品和生物医学方面显示出巨大的应用潜力。这些生物活性由其复杂的分子结构精确调节。然而，这种精确调节背后的机制尚未完全被理解，并且仍在不断发展。本文对最具代表性的 MP 物种进行了全面综述，包括其发酵和纯化过程及其近年来的生物医学应用。特别是，这项工作对 MP 在多个分子水平上的结构-活性关系进行了深入分析。此外，这篇综述讨论了研究结构-活性关系的挑战和前景，为 MP 的广泛和高价值利用提供了宝贵的见解。
更新日期：2024-03-21
中文翻译：
微生物多糖生物活性的结构-功能洞察在生物医学应用中的应用：综述
微生物多糖（MPs）是细菌、真菌等微生物在代谢过程中分泌的生物聚合物。与动植物多糖相比，MPs具有来源广、生产效率高、不易受自然环境影响等优点。 MP最吸引人的特点在于其多样化的生物活性，如抗氧化、抗肿瘤、抗菌和免疫调节活性，这些活性在功能性食品、化妆品和生物医学方面显示出巨大的应用潜力。这些生物活性由其复杂的分子结构精确调节。然而，这种精确调节背后的机制尚未完全被理解，并且仍在不断发展。本文对最具代表性的 MP 物种进行了全面综述，包括其发酵和纯化过程及其近年来的生物医学应用。特别是，这项工作对 MP 在多个分子水平上的结构-活性关系进行了深入分析。此外，这篇综述讨论了研究结构-活性关系的挑战和前景，为 MP 的广泛和高价值利用提供了宝贵的见解。
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