<br>天麻素通过调节 CUMS 诱导小鼠的肠道微生物群改善抑郁样行为,Behavioural Brain Research

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天麻素通过调节 CUMS 诱导小鼠的肠道微生物群改善抑郁样行为
Behavioural Brain Research ( IF 2.6 ) Pub Date : 2024-03-21 , DOI: 10.1016/j.bbr.2024.114968
Yanan Zhao ₁ , Shaokun Qin ₂ , Zixian Yang ₃ , Ye Lu ₄ , Zongmin Ma ₄ , Xin Ping ₅ , Guoqiang Sun ₄ , Lin Pei ₄

Affiliation

抑郁症是一种精神疾病，抑郁症的治疗是亟待解决的问题。天麻素 (GAS) 是一种来自兰花的中药，用于治疗神经系统疾病，包括抑郁症。为了评估 GAS 对抑郁小鼠肠道微生物群的影响，我们建立了慢性不可预测轻度应激 (CUMS) 诱导的小鼠模型，并向其中一组小鼠施用 GAS。采用动物行为实验检测抑郁样行为，并应用16S rRNA基因分析检测各组肠道微生物群。所有原始序列均存放在 NCBI 序列读取存档中，登录号为 SRP491061。 GAS 治疗显着改善了抑郁样行为以及肠道微生物群的多样性和丰度。 CUMS-GAS组的抑郁样行为较CUMS组有不同程度的改善。肠道菌群的线性判别分析（LDA）显示，CUMS-GAS组小鼠肠道菌群的组成发生了显着变化，与CUMS组相比，拟杆菌（LDA = 3.94，P < 0.05）富集属水平的 CUMS-GAS 组。与CUMS组相比，CUMS-GAS组的乳酸菌、棒状杆菌、葡萄球菌、类杆菌、冷杆菌和Alistipes的浓度更高。我们的结果表明，GAS 改善了小鼠的抑郁样行为，并影响了肠道的微生物组成。我们的研究表明，肠道微生物群的失调可能会受到 GAS 治疗的影响，GAS 治疗改善了 CUMS 诱导的抑郁小鼠模型中的抑郁样行为。

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Gastrodin ameliorates depressive-like behaviors via modulating gut microbiota in CUMS-induced mice

Depression is a psychiatric disorder and the treatment of depression is an urgent problem that need to be solved. Gastrodin (GAS) is a Traditional Chinese Medicine from an orchid and is used for neurological diseases, including depressive disorders. To assess the effect of GAS on gut microbiota of depressive mice, we established a chronic unpredictable mild stress (CUMS)-induced mouse model, and GAS was administered to one group of the mice. Animal behavior experiments were used to detect depressive-like behaviors, and 16 S rRNA gene analysis was applied to detect the gut microbiota of each group. All raw sequences were deposited in the NCBI Sequence Read Archive under accession number SRP491061. GAS treatment significantly improved depressive-like behaviors as well as the diversity and abundance of the gut microbiota. The depressive-like behaviors of the CUMS-GAS group were improved in different degrees compared with the CUMS group. The linear discriminant analysis (LDA) of the gut microbiota showed that the makeup of the gut microbiota in mice changed dramatically in the CUMS-GAS group, compared with the CUMS group, Bacteroides (LDA = 3.94, P < 0.05) were enriched in the CUMS-GAS group at the genus level. In comparison to the CUMS group, the CUMS-GAS group had a greater concentration numbers of Lactobacillus, Corynebacterium, Staphylococcus, Bacteroides, Psychrobacter, and Alistipes. Our results suggested that GAS improved depressive-like behaviors in mice and impacted the microbial composition of the gut. Our research indicated that dysbiosis of the gut microbiota may be affected by GAS treatment, which improved depressive-like behaviors in the CUMS-induced mouse model of depression.

更新日期：2024-03-21

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