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Bridging the gap between testing and clinics exploring alternative pre-clinical models in melanoma research
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-03-23 , DOI: 10.1016/j.addr.2024.115295 Juliana Viegas 1 , Bruno Sarmento 2
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-03-23 , DOI: 10.1016/j.addr.2024.115295 Juliana Viegas 1 , Bruno Sarmento 2
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Melanoma, the deadliest form of skin cancer, poses a significant clinical challenge for the development of effective treatments. Conventional animal studies have shown limited translational relevance to humans, raising strength to pre-clinical models for melanoma research. This review provides an in-depth analysis of alternative pre-clinical models including and platforms such as reconstructed skin, spheroids, organoids, organotypic models, skin-on-a-chip, and bioprinting. Through a comprehensive analysis, the specific attributes, advantages, and limitations of each model are elucidated. It discusses the points related to the uniqueness advantages, from capturing complex interactions between melanoma cells and their microenvironment to enabling high-throughput drug screening and personalized medicine approaches. This review is structured covering firstly the roadmap to identify the co-occurrence of discovering new melanoma treatments and the development of its models, secondly it covers a comparative between the most used models followed by a section discussing each of them: the and models. It intends to serve as an asset for researchers of melanoma field and clinicians involved in melanoma therapy, offering insights into the diverse preclinical models available for optimizing their integration into the translational pipeline.
中文翻译：
弥合测试和临床之间的差距，探索黑色素瘤研究中的替代临床前模型
黑色素瘤是最致命的皮肤癌，对开发有效的治疗方法提出了重大的临床挑战。传统的动物研究表明与人类的转化相关性有限，这提高了黑色素瘤研究的临床前模型的强度。本综述对替代临床前模型进行了深入分析，包括重建皮肤、球体、类器官、器官模型、芯片皮肤和生物打印等平台。通过综合分析，阐明了每种模型的具体属性、优点和局限性。它讨论了与独特优势相关的要点，从捕获黑色素瘤细胞与其微环境之间的复杂相互作用到实现高通量药物筛选和个性化医疗方法。这篇综述的结构首先涵盖了确定新黑色素瘤治疗方法及其模型开发同时发生的路线图，其次涵盖了最常用模型之间的比较，然后是讨论每个模型的部分：和模型。它旨在成为黑色素瘤领域的研究人员和参与黑色素瘤治疗的临床医生的资产，提供对可用于优化其与转化管道的整合的各种临床前模型的见解。
更新日期：2024-03-23
中文翻译：
弥合测试和临床之间的差距，探索黑色素瘤研究中的替代临床前模型
黑色素瘤是最致命的皮肤癌，对开发有效的治疗方法提出了重大的临床挑战。传统的动物研究表明与人类的转化相关性有限，这提高了黑色素瘤研究的临床前模型的强度。本综述对替代临床前模型进行了深入分析，包括重建皮肤、球体、类器官、器官模型、芯片皮肤和生物打印等平台。通过综合分析，阐明了每种模型的具体属性、优点和局限性。它讨论了与独特优势相关的要点，从捕获黑色素瘤细胞与其微环境之间的复杂相互作用到实现高通量药物筛选和个性化医疗方法。这篇综述的结构首先涵盖了确定新黑色素瘤治疗方法及其模型开发同时发生的路线图，其次涵盖了最常用模型之间的比较，然后是讨论每个模型的部分：和模型。它旨在成为黑色素瘤领域的研究人员和参与黑色素瘤治疗的临床医生的资产，提供对可用于优化其与转化管道的整合的各种临床前模型的见解。
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