Clinical perspective on topical vaccination strategies,Advanced Drug Delivery Reviews

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Clinical perspective on topical vaccination strategies
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-03-24 , DOI: 10.1016/j.addr.2024.115292
Petya G Popova ₁ , Sunny P Chen ₁ , Suiyang Liao ₂ , Manish Sadarangani ₃ , Anna K Blakney ₁

Affiliation

Vaccination is one of the most successful measures in modern medicine to combat diseases, especially infectious diseases, and saves millions of lives every year. Vaccine design and development remains critical and involves many aspects, including the choice of platform, antigen, adjuvant, and route of administration. Topical vaccination, defined herein as the introduction of a vaccine to any of the three layers of the human skin, has attracted interest in recent years as an alternative vaccination approach to the conventional intramuscular administration because of its potential to be needle-free and induce a superior immune response against pathogens. In this review, we describe recent progress in developing topical vaccines, highlight progress in the development of delivery technologies for topical vaccines, discuss potential factors that might impact the topical vaccine efficacy, and provide an overview of the current clinical landscape of topical vaccines.

中文翻译：

局部疫苗接种策略的临床视角

疫苗接种是现代医学对抗疾病特别是传染病最成功的措施之一，每年挽救数百万人的生命。疫苗的设计和开发仍然至关重要，涉及许多方面，包括平台、抗原、佐剂和给药途径的选择。局部疫苗接种在本文中定义为将疫苗引入人体皮肤三层中的任何一层，近年来作为传统肌肉注射的替代疫苗接种方法引起了人们的兴趣，因为它具有无针头并诱导疫苗接种的潜力。针对病原体的卓越免疫反应。在这篇综述中，我们描述了开发外用疫苗的最新进展，重点介绍了外用疫苗递送技术开发的进展，讨论了可能影响外用疫苗功效的潜在因素，并概述了当前外用疫苗的临床情况。

更新日期：2024-03-24

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