HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases,Molecular Neurodegeneration

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HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases
Molecular Neurodegeneration ( IF 14.9 ) Pub Date : 2024-03-27 , DOI: 10.1186/s13024-024-00718-8
Anna Calliari ₁ , Lillian M Daughrity ₁ , Ellen A Albagli ₁ , Paula Castellanos Otero ₁ , Mei Yue ₁ , Karen Jansen-West ₁ , Naeyma N Islam ₁ , Thomas Caulfield ₁ , Bailey Rawlinson ₁ , Michael DeTure _{1,

2} , Casey Cook _{1,

2} , Neill R Graff-Radford ₃ , Gregory S Day ₃ , Bradley F Boeve ₄ , David S Knopman ₄ , Ronald C Petersen ₄ , Keith A Josephs ₄ , Björn Oskarsson ₃ , Aaron D Gitler ₅ , Dennis W Dickson _{1,

2} , Tania F Gendron _{1,

2} , Mercedes Prudencio _{1,

2} , Michael E Ward _{6,

7} , Yong-Jie Zhang _{1,

2} , Leonard Petrucelli _{1,

2}

Affiliation

This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.

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