There is considerable interest in developing anti-glioma nanoplatforms. They make the all-in-one combination of therapies possible. Here we show how the selective Glioblastoma multiforme (GBM) cell killing of the here-established nanoplatforms increased after each coating and how the here-established vibration-inducing Alternating magnetic field (AMF) decreased the treatment time from 72 h to 30 s. Thanks to their magnetite core, these nanoplatforms can be guided to the tumor's specific site by a Fixed magnetic field, they bypass the Blood–Brain Barrier (BBB) and accumulate at the tumor site thanks to the RVG29 bonding to the G-protein on the ion-gated channel receptor known as the nicotinic acetylcholine receptor (nAchR), which expresses on BBB cells and overexpresses on GBM cells, and thanks to the positive charge gained by both chitosan and RVG29's peptide. Both ZIF-8 and its mediate adherence, Chitosan increases the drug loading capacity that stimuli response to the tumor's acidic environment. The Zn²⁺ ions generated from ZIF-8 sustained degradation in such an environment kill the GBM cells. Dynamic Light Scattering (DLS) evaluated these nanoplatform's mean size 155 nm indicating their almost optimum size for brain applications. Based on their elements' intrinsic properties, these nanoplatforms can enhance and combine other adjuvant therapies.

人们对开发抗神经胶质瘤纳米平台有相当大的兴趣。它们使多合一的疗法组合成为可能。在这里，我们展示了每次涂层后，这里建立的纳米平台的选择性多形性胶质母细胞瘤 （GBM） 细胞杀伤如何增加，以及这里建立的振动诱导交变磁场 （AMF） 如何将治疗时间从 72 小时减少到 30 秒。由于它们的磁铁矿核心，这些纳米平台可以通过固定磁场引导到肿瘤的特定部位，它们绕过血脑屏障 （BBB） 并在肿瘤部位积累，这要归功于 RVG29 与离子门控通道受体上的 G 蛋白结合，称为烟碱乙酰胆碱受体 （nAchR），它在 BBB 细胞上表达并在 GBM 细胞上过表达， 并且由于壳聚糖和 RVG29 肽都获得了正电荷。ZIF-8 及其介导的粘附性壳聚糖增加了刺激对肿瘤酸性环境反应的药物负载能力。ZIF-8 产生的 Zn²⁺ 离子在这种环境中持续降解杀死 GBM 细胞。动态光散射 （DLS） 评估了这些纳米平台的平均尺寸 155 nm，表明它们几乎是大脑应用的最佳尺寸。根据其元素的内在特性，这些纳米平台可以增强和结合其他辅助疗法。