Thiophene-2-carbonyl chloride (TCC) is the key raw material in the preparation of tioxazafen, a proprietary seed treatment that was being developed by Bayer AG as a broad-spectrum nematicide. Current manufacturing routes to TCC suffer from side product formation and significant waste generation, which lead to high manufacturing costs. A new and potentially more cost-effective process to prepare TCC from thiophene has been developed. The key step in the process utilizes homogeneous liquid-phase aerobic oxidation of 2-acetylthiophene (AcT). This article describes development details for each of the three steps involved in the new process.

中文翻译：

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利用催化液相有氧氧化反应制备噻唑芬合成的关键原料噻吩-2-甲酰氯的新工艺

噻吩-2-碳酰氯 ( TCC ) 是制备 Tioxazafen 的关键原材料，tioxazafen 是拜耳公司正在开发的一种专利种子处理剂，作为广谱杀线虫剂。当前的TCC制造路线存在副产物形成和大量废物产生的问题，从而导致制造成本高昂。一种从噻吩制备TCC 的新且可能更具成本效益的工艺已经开发出来。该工艺的关键步骤是利用 2-乙酰噻吩 ( AcT )的均相液相有氧氧化。本文描述了新流程中涉及的三个步骤中每个步骤的开发细节。