Aims To examine differences between the eyes in choriocapillaris perfusion and choroidal thickness in children with myopic anisometropia. Methods In this observational and prospective study, 46 children with myopic anisometropia were enrolled. Choriocapillaris perfusion parameters, including the percentage of flow voids, the total number of flow voids and the average flow void area were obtained by optical coherence tomography angiography (OCTA). The OCTA image was divided into a 1 mm-diameter central circle (C1) and a 2.5 mm-diameter annulus (without the inner central 1 mm circle, C1-2.5). Both C1 and C1-2.5 are centred on the foveola. The C1-2.5 was divided into nasal (N1-2.5), temporal (T1-2.5), inferior (I1-2.5) and superior (S1-2.5) areas. Differences in these parameters in different regions between eyes were analysed. Results There were no significant differences in the percentage of flow voids and the average flow void area between the fellow eyes. The total number of signal voids was significantly higher in the less myopic eyes in C1-2.5 (p=0.032), S1-2.5 (p=0.008) and N1-2.5 (p=0.019). Changes in spherical equivalent refraction and axial length were both correlated with the changes in the total number of flow voids in N1-2.5 (R=−0.431, p=0.03; R=−0.297, p=0.047). Conclusions The choroid in the macular region becomes thinner and the total number of flow voids in the nasal macular region decreased with the amplitude of myopia. This suggests that a decrease in total number of flow voids may indicate an early change in myopia. No data are available.

中文翻译：

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近视屈光参差患儿的脉络膜毛细血管血流特征


目的 探讨近视性屈光参差患儿绒毛毛管灌注和脉络膜厚度的眼型差异。方法 在这项观察性和前瞻性研究中，纳入了 46 例近视屈光参差患儿。通过光学相干断层扫描血管造影 （OCTA） 获得脉络膜毛细血管灌注参数，包括血流空隙百分比、血流空隙总数和平均血流空隙面积。OCTA 图像分为直径为 1 mm 的中心圆 （C1） 和直径为 2.5 mm 的环形 （没有内部中心 1 mm 圆 C1-2.5）。C1 和 C1-2.5 都集中在中央凹。将 C1-2.5 分为鼻 （N1-2.5） 、颞部 （T1-2.5） 、下部 （I1-2.5） 和上部 （S1-2.5） 区。分析了眼睛之间不同区域这些参数的差异。结果 对侧眼之间血流空隙百分比和平均血流空隙面积无显著差异。C1-2.5 （p = 0.032） 、 S1-2.5 （p = 0.008） 和 N1-2.5 （p = 0.019） 中近视较轻的眼睛信号空隙总数显著增加。球面等效折射和轴向长度的变化都与 N1-2.5 中流动空隙总数的变化相关 （R=-0.431，p=0.03;R=−0.297，p=0.047）。结论 随着近视的幅度，黄斑区脉络膜变薄，鼻部黄斑区血流空隙总数减少。这表明血流排尿总数的减少可能表明近视的早期变化。没有可用的数据。