This research demonstrates that the integration of unnatural amino acids (L- or D-4,4′-biphenylalanine) into peptide assemblies significantly accelerates their accumulation within prostate cancer cells, boosting their capacity to hinder cancer proliferation. This work paves a way for engineering supramolecular medicine, potentially heightening the efficacy of peptide-based treatments for prostate cancer. It may lead to more effective therapeutic strategies for treating other cancers.

中文翻译：

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加速细胞摄取非天然氨基酸以抑制免疫抑制癌细胞


这项研究表明，非天然氨基酸（L-或D-4,4'-联苯丙氨酸）整合到肽组装中可显着加速其在前列腺癌细胞内的积累，从而增强其阻碍癌症增殖的能力。这项工作为超分子医学工程铺平了道路，有可能提高基于肽的前列腺癌治疗的疗效。它可能会导致治疗其他癌症的更有效的治疗策略。