Presently several beta emitting radionuclides are in use as brachytherapy sources, due to their inherent advantages of short-range radiation dose delivery compared to their gamma emitting counterparts. ⁹⁰Y is one of the well-known hard beta-emitting radioisotopes for the therapeutic application of radioactivity. Among various other modalities, ⁹⁰Y resin microsphere as a brachytherapy source has its application for liver cancer. In the present study, ⁹⁰Y was recovered from ^235,238U,²³⁹Pu(n_fast,f)⁹⁰Sr(β⁻)⁹⁰Y using Sr selective crown ether followed by quick purification using the Ion Chromatography technique. The purified ⁹⁰Y was labelled in strong cation exchange resin to form ⁹⁰Y resin microsphere. Various quality control parameters, e.g., water solubility, chemical, radionuclidic purity, and half-life, were verified using Gamma spectrometry, Cerenkov, and Liquid Scintillation Counting techniques. The obtained half-life was 64.05 h, which is in excellent agreement with the literature and is indirect evidence of the very high radionuclidic purity of the sample. A rapid method for the synthesis of ⁹⁰Y resin microsphere brachytherapy source is being reported for the first time after its recovery from irradiated fast reactor fuel dissolver solution. After the separation of ⁹⁰Sr along with trace level impurities inside the hot cell, simultaneous purification of parent ⁹⁰Sr and daughter ⁹⁰Y using single-stage Ion Chromatography step takes 15–25 min only in comparison to 24 h or more time using multistage conventional Ion exchange chromatography column, which saves the separation time and in turn, increase the yield of ⁹⁰Y per separation campaign.

目前，几种β发射放射性核素被用作近距离放射治疗源，因为与伽马发射放射性核素相比，它们具有短程辐射剂量输送的固有优势。⁹⁰ Y 是用于放射性治疗应用的众所周知的硬β发射放射性同位素之一。在各种其他治疗方式中，⁹⁰ Y 树脂微球作为近距离放射治疗源可用于肝癌治疗。在本研究中，使用Sr选择性冠醚从^235,238 U, ²³⁹ Pu(n _fast ,f) ⁹⁰ Sr(β ^- ) ⁹⁰ Y中回收⁹⁰ Y，然后使用离子色谱技术进行快速纯化。将纯化后的⁹⁰ Y标记在强阳离子交换树脂中，形成⁹⁰ Y树脂微球。使用伽马能谱、切伦科夫和液体闪烁计数技术验证了各种质量控制参数，例如水溶性、化学、放射性核素纯度和半衰期。获得的半衰期为 64.05 小时，这与文献非常一致，并且是样品具有非常高的放射性核素纯度的间接证据。首次报道了从辐照快堆燃料溶解溶液中回收⁹⁰ Y树脂微球近距离治疗源的快速合成方法。在热池内分离⁹⁰ Sr 以及痕量杂质后，使用单级离子色谱步骤同时纯化母体⁹⁰ Sr 和子体⁹⁰ Y 仅需要 15-25 分钟，而使用多级传统色谱步骤则需要 24 小时或更长时间离子交换色谱柱可节省分离时间，从而提高每次分离活动^{90 Y 的产量。}