Many recent studies have indicated that some modified silicate glass–ceramics are considered and recommended to be part of the process of dental applications. Examples from the recommended glass–ceramics include modified lithium silicate with various dopants (ZrO₂, CeO₂), mica-based glass–ceramics, and leucite-based glass–ceramics. The present study employs a new direction of research in the preparation of modified lithium silicate glasses containing varying dopant percents of ZrO₂ to produce the parent glasses using nano-silica as an essential chemical component in comparison with silica. The ZrO₂-doped glass–ceramic reveals the crystalline phase of lithium aluminosilicate (Li₅AlSi₂O₈) due to the effect of ZrO₂. The modified lithium silicate glasses doped with ZrO₂ prepared from nano silica indicate their high mechanical properties and can be primarily recommended for dental applications.