A clear classification of the subtype and grade of soft tissue sarcoma is important for predicting prognosis and establishing treatment strategies. However, the rarity and heterogeneity of these tumors often make diagnosis difficult. In addition, it remains challenging to predict the response to chemotherapy and prognosis. Thus, we need a new method to help diagnose soft tissue sarcomas and determine treatment strategies in conjunction with traditional methods. Genetic alterations can be found in some subtypes of soft tissue sarcoma, but many other types show dysregulated gene expression attributed to epigenetic changes, such as DNA methylation status. However, research on DNA methylation profiles in soft tissue sarcoma is still insufficient to provide information to assist in diagnosis and therapeutic decisions.

中文翻译：

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DNA 甲基化分析能否对软组织肉瘤的组织学亚型和等级进行分类？


软组织肉瘤的亚型和分级的明确分类对于预测预后和制定治疗策略具有重要意义。然而，这些肿瘤的罕见性和异质性往往使诊断变得困难。此外，预测化疗的反应和预后仍然具有挑战性。因此，我们需要一种新的方法来帮助诊断软组织肉瘤并结合传统方法确定治疗策略。在软组织肉瘤的某些亚型中可以发现基因改变，但许多其他类型的软组织肉瘤由于表观遗传变化（例如 DNA 甲基化状态）而表现出基因表达失调。然而，对软组织肉瘤 DNA 甲基化谱的研究仍不足以提供协助诊断和治疗决策的信息。