Tumor-associated macrophages (TAMs) constitute an important part of the tumor microenvironment (TME) that regulates tumor progression. Tumor-derived signals, hypoxia, and competition for nutrients influence TAMs to reprogram their cellular metabolism. This altered metabolic profile creates a symbiotic communication between tumor and other immune cells to support tumor growth. In addition, the metabolic profile of TAMs regulates the expression of immune checkpoint molecules. The dynamic plasticity also allows TAMs to reshape their metabolism in response to modern therapeutic strategies. Therefore, over the years, a significant number of approaches have been implicated to reprogram cancer-promoting metabolism in TAMs. In this review, we discuss the current strategies and pitfalls, along with upcoming promising opportunities in leveraging TAM metabolism for developing better therapeutic approaches against cancer.

肿瘤相关巨噬细胞（TAM）是调节肿瘤进展的肿瘤微环境（TME）的重要组成部分。肿瘤源性信号、缺氧和营养竞争会影响 TAM 重新编程其细胞代谢。这种改变的代谢特征在肿瘤和其他免疫细胞之间建立了共生通讯，以支持肿瘤生长。此外，TAM 的代谢特征调节免疫检查点分子的表达。动态可塑性还允许 TAM 重塑其新陈代谢，以响应现代治疗策略。因此，多年来，大量方法涉及重新编程 TAM 中促进癌症的代谢。在这篇综述中，我们讨论了当前的策略和陷阱，以及即将到来的利用 TAM 代谢开发更好的癌症治疗方法的有希望的机会。