Plant-derived bioactive compounds displayed major therapeutic and chemo-preventive roles in the pathogenesis of numerous chronic malignancies such as cancer and enhanced oxidative stress and inflammation. Antioxidants found in food, such as genkwanin, may reduce oxidative stress and the release of cytokines or pathways that promote inflammation. The goal of this work is to summarize the potential for anticancer effects of genkwanin, a methoxyflavone that is present in a variety of plant species. This review examined and analyzed numerous research studies on identifying, isolating, measuring, and analyzing anticancer properties of genkwanin. The mechanisms involved cellular and molecular activities at various levels, including apoptosis induction and cancer cell growth and proliferation inhibition. Preclinical studies have demonstrated genkwanin’s effects and mechanism of action; however, further research is required to investigate its therapeutic potential thoroughly. Additional research is needed to further our understanding of the pharmacodynamic effects of genkwanin. Additional toxicological study is necessary to evaluate the clinical efficacy and safety of genkwanin, which would help scientists to elucidate a potent drug candidate for cancer management.

中文翻译：

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全面综述揭示了芫花素（植物源性化合物）在多种人类癌症中的抗癌潜力

植物源性生物活性化合物在许多慢性恶性肿瘤（例如癌症）以及增强的氧化应激和炎症的发病机制中显示出主要的治疗和化学预防作用。食物中发现的抗氧化剂，例如芫花素，可以减少氧化应激和促进炎症的细胞因子或途径的释放。这项工作的目的是总结芫花素（一种存在于多种植物物种中的甲氧基黄酮）的抗癌作用潜力。这篇综述审查并分析了许多有关鉴定、分离、测量和分析芫花素抗癌特性的研究。这些机制涉及各个层面的细胞和分子活动，包括细胞凋亡诱导和癌细胞生长和增殖抑制。临床前研究已经证明了芫花素的作用和作用机制；然而，还需要进一步的研究来彻底调查其治疗潜力。需要进行更多研究来进一步了解芫花素的药效作用。需要进行额外的毒理学研究来评估芫花素的临床功效和安全性，这将有助于科学家阐明用于癌症治疗的有效候选药物。