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Visual acuity and visual field as a function of disease duration in patients with birdshot chorioretinitis
British Journal of Ophthalmology ( IF 3.7 ) Pub Date : 2024-11-01 , DOI: 10.1136/bjo-2023-324636
Jordan Loeliger 1 , Dominique Monnet 1 , Jennifer Thorne 2 , Linda Imikerene 1 , Souhila Kecili 1 , Antoine P Brézin 3
Affiliation  

Background Birdshot chorioretinitis (BSCR) is a chronic bilateral posterior uveitis, which can affect central as well as peripheral vision. The aim of this study was to assess how visual acuity and visual field evolved over time in patients with BSCR. Methods This was a prospective, observational, single-centre study based on data from the CO-BIRD cohort. Patient visits were categorised based on the time elapsed since the first symptoms, and groups of patients with different disease duration were defined. The main outcome measures were the best corrected visual acuity (BCVA), the mean deviation (MD) and the standard pattern deviation (PSD). Results The study included 447 Caucasian patients (181 males and 266 females), all of whom HLA-A29 carriers. From onset to 30 years of disease duration, the number of patients in each consecutive 5-year period was 237, 250, 196, 147, 78 and 32, respectively. Overall, the range of visual acuity and visual field results increased with disease duration. BCVA gradually decreased and showed a significant decline after 11–15 years after the first symptoms. Among the visual field indices, PSD significantly increased after 16–20 years, while MD showed a significant decline after 21–25 years. No major gender differences were found in visual outcomes, indicating comparable severity. The intereye correlations of MD and PSD were stronger than those of BCVA. Conclusions BSCR resulted in a large heterogeneity of visual outcomes, which increased with time. Our data provide an overview of the visual consequences of BSCR as a function of disease duration. Data are available on reasonable request.

中文翻译:


鸟弹状脉络膜视网膜炎患者的视力和视野与病程的关系



背景 鸟弹状脉络膜视网膜炎 (BSCR) 是一种慢性双侧后葡萄膜炎,可影响中央和周边视力。本研究的目的是评估 BSCR 患者的视力和视野如何随着时间的推移而变化。方法 这是一项基于 CO-BIRD 队列数据的前瞻性、观察性、单中心研究。根据自首次症状以来经过的时间对患者就诊进行分类,并定义不同病程的患者组。主要结局指标是最佳矫正视力 (BCVA) 、平均偏差 (MD) 和标准模式偏差 (PSD)。结果 该研究包括 447 名白人患者 (181 名男性和 266 名女性),他们都是 HLA-A29 携带者。从发病到病程 30 年,每个连续 5 年期间的患者人数分别为 237 、 250 、 196、 147 、 78 和 32 。总体而言,视力和视野结果的范围随着疾病持续时间的增加而增加。BCVA 逐渐下降,并在首次症状出现后 11-15 年后出现显着下降。在视野指数中,PSD 在 16-20 年后显著增加,而 MD 在 21-25 年后显著下降。在视觉结局中未发现重大性别差异,表明严重程度相当。MD 和 PSD 的眼间相关性强于 BCVA。结论 BSCR 导致视觉结果存在很大异质性,且异质性随时间增加。我们的数据概述了 BSCR 的视觉后果与疾病持续时间的关系。数据可应合理要求提供。
更新日期:2024-10-22
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