Abstract

Method for the preparation of N-arylamino-1,2,4-oxadiazol-5(4H)-ones via reduction of N-nitrophenyl-1,2,4-oxadiazol-5(4H)-ones with tin(II) chloride has been developed. The results of experiments to study photophysical properties showed that the synthesized compounds have potential for use as fluorophores in the visible region of the spectrum. In addition, one of the obtained N-arylamino-1,2,4-oxadiazol-5(4H)-ones demonstrate antibacterial activity against both Gram-positive (S. Aureus) and Gram-negative (E. Coli) strains.

中文翻译：

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N-芳氨基-1,2,4-恶二唑-5(4H)-酮：合成、发光、抗菌和抗肠病毒特性

摘要

用锡(II)还原N-硝基苯基-1,2,4-恶二唑-5(4H ) -酮制备N-芳基氨基-1,2,4-恶二唑-5(4H ) -酮的方法）氯化物已经开发出来。研究光物理性质的实验结果表明，合成的化合物具有用作光谱可见区荧光团的潜力。此外，所获得的N-芳基氨基-1,2,4-恶二唑-5(4H ) -酮之一表现出对革兰氏阳性（金黄色葡萄球菌）和革兰氏阴性（大肠杆菌）菌株的抗菌活性。