Seven new triterpenoids from the roots of Adenophora tetraphylla (Thub.) Fisch,Fitoterapia

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Seven new triterpenoids from the roots of Adenophora tetraphylla (Thub.) Fisch
Fitoterapia ( IF 2.5 ) Pub Date : 2024-03-16 , DOI: 10.1016/j.fitote.2024.105902
Zhe-Yue Han ₁ , Jia-Tong Wu ₁ , Yu-Xuan Lin ₁ , Yu Bi ₁ , Anam Naseem ₁ , Zhi-Chao Hao ₁ , Juan Pan ₁ , Wei Guan ₁ , Hai-Xue Kuang ₁ , Qing-Shan Chen ₁ , Li-Li Zhang ₁ , Yan Liu ₁ , Bing-You Yang ₁

Affiliation

Seven new triterpenoids, named Adeterpenoids A-G (–) and eight known compounds (–), were isolated from 70% ethanol extract of the roots of (Thub.) Fisch. The compounds from it were separated by column chromatography techniques such as silica gel, ODS, and preparative liquid chromatography. Their structures were clarified based on extensive spectral analysis (1D, 2D-NMR, HR-ESI-MS, IR, UV, and CD) and comparison with the literature. At the same time, all compounds were evaluated for their cytotoxic activity against the LN229 (human glioma cell line). The results showed that compounds , , , and had a significant inhibitory effect on LN229 cells.

中文翻译：

来自沙参根的七种新三萜类化合物

从 (Thub.) Fisch 根的 70% 乙醇提取物中分离出七种新的三萜类化合物，命名为 Adeterpenoids AG (-) 和八种已知化合物 (-)。通过硅胶、ODS、制备型液相色谱等柱色谱技术分离其中的化合物。基于广泛的光谱分析（1D、2D-NMR、HR-ESI-MS、IR、UV 和 CD）以及与文献的比较，阐明了它们的结构。同时，评估了所有化合物针对 LN229（人神经胶质瘤细胞系）的细胞毒活性。结果表明化合物、、、、对LN229细胞有显着的抑制作用。

更新日期：2024-03-16

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