<br>基于 PLGA 的药物输送系统：一种有前景的抗糖尿病药物输送载体,Advanced Therapeutics

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基于 PLGA 的药物输送系统：一种有前景的抗糖尿病药物输送载体
Advanced Therapeutics ( IF 3.7 ) Pub Date : 2024-03-21 , DOI: 10.1002/adtp.202300424
Bhaben Sharmah _{1,

2} , Amarjit Borthakur ₁ , Prasenjit Manna _{1,

2}

Affiliation

聚乳酸-乙醇酸 (PLGA) 纳米颗粒由于其生物降解性、生物相容性和可调节的释放动力学，已成为药物输送的多功能平台。 PLGA 纳米颗粒在糖尿病管理中的主要应用之一是胰岛素的封装和控制释放，克服了频繁注射的局限性。此类系统提供持续稳定的血糖控制，降低低血糖风险。不同类型的PLGA及其衍生物可用于制备各种微/纳米载体以输送胰岛素以及多种抗糖尿病分子，包括胰高血糖素样肽-1（GLP-1）及其类似物（exendin-4）、藏花酸、二甲双胍盐酸、格列齐特、阿魏酸（FA）等，降低高血糖。本文总结了用于糖尿病管理的基于 PLGA 的药物输送系统的研究和开发现状。探索了用于增强 PLGA 纳米颗粒在糖尿病治疗中的靶向特异性的各种策略。该结果将深入了解 PLGA 在控制高血糖方面的药物输送潜力和效率，并将有助于设计新的治疗方法以更好地控制糖尿病。随着该领域研究的不断进展，基于 PLGA 的系统具有彻底改变糖尿病治疗模式的巨大潜力。

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PLGA-Based Drug Delivery Systems: A Promising Carrier for Antidiabetic Drug Delivery

Poly(lactic-co-glycolic acid) (PLGA) nanoparticles have emerged as a versatile platform for drug delivery due to their biodegradability, biocompatibility, and tunable release kinetics. One of the primary applications of PLGA nanoparticles in diabetes management is the encapsulation and controlled release of insulin, overcoming the limitations of frequent injections. Such systems provide sustained and stable glycemic control, reducing the risk of hypoglycemia. Different types of PLGAs and their derivatives are used for preparing varieties of micro/nanocarriers to deliver insulin as well as diverse antidiabetic molecules, including glucagon-like peptide-1 (GLP-1) and its analog (exendin-4), crocetin, metformin hydrochloride, gliclazide, ferulic acid (FA), etc., to reduce hyperglycemia. Here the current state of research and development in PLGA-based drug delivery systems for diabetes management are summarized. Various strategies employed to enhance the targeting specificity of PLGA nanoparticles in diabetes therapy are explored. The outcome will provide an insight into the drug delivery potential and efficiency of PLGA in managing hyperglycemia and that will be useful in designing novel therapeutic to improve better control of diabetes mellitus. As research in this field continues to progress, PLGA-based systems hold great potential for revolutionizing the treatment paradigm for diabetes mellitus.

更新日期：2024-03-21

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