Transcriptional regulators generate connections between biological signals and genetic outputs. They are used robustly for sensing input signals in building genetic circuits. However, each regulator can only generate a fixed connection, which generates constraints in linking multiple signals for more complex processes. Recent studies discovered that a domain swapping strategy can be applied to various regulator families to create modular regulators for new signal-output connections, significantly broadening possibilities in circuit design. Here we review the development of this emerging strategy, the use of resulting modular regulators for creating novel genetic response behaviors, and current limitations and solutions for further advancing the design of modular regulators.

中文翻译：

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一种域交换策略，用于为遗传网络中的新型拓扑创建模块化转录调节因子

转录调节因子在生物信号和遗传输出之间产生联系。它们被广泛用于传感构建遗传电路中的输入信号。然而，每个调节器只能生成固定连接，这在链接多个信号以实现更复杂的过程时产生了限制。最近的研究发现，域交换策略可以应用于各种稳压器系列，为新的信号输出连接创建模块化稳压器，从而显着拓宽电路设计的可能性。在这里，我们回顾了这一新兴策略的发展、使用由此产生的模块化调节器来创建新颖的遗传反应行为，以及进一步推进模块化调节器设计的当前限制和解决方案。