The growing pace of two-dimensional (2D) transitional metal carbides and nitrides (MXenes) has become a spotlight for recent research. Similarly, the need to close the gap left by conventional antibiotics, fighting off bacterial infections, and drug resistance has become eminent. Especially, MXenes are widely used as excellent photothermal agents. However, there are limited reports on MXenes as sonosensitizer. Herein, a high-entropy MXene (HEM), TVNMC was fabricated for the generation of reactive oxide species (ROS) against Methicillin-resistance (MRSA). Interestingly the energy storage and conversion from the diverse composition of the TVNMC MXenes allowed the generation of ROS under US irradiation and even enhanced under Photothermal therapy. This combinatorial therapy undertook a near-total kill and eradication of MRSA with its biofilm. Moreover, TVNMC MXene simultaneously eliminated MRSA abscesses while promoting wound healing with negligible anomaly to murine tissues under sonodynamic and photothermal therapy, making the TVNMC MXene a promising sonosensitizer for possible biomedical usage. Overall, this system provides great potential for the use of high-entropy MXenes as a new type of sonosensitizer in anti-infection therapy.

中文翻译：

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NIR-II 放大基于 MXene 的高熵声敏剂，声动力疗法可促进耐甲氧西林金黄色葡萄球菌感染的伤口愈合


二维 (2D) 过渡金属碳化物和氮化物 (MXene) 的增长速度已成为近期研究的焦点。同样，缩小传统抗生素留下的差距、对抗细菌感染和耐药性的需求也变得十分紧迫。特别是，MXenes 作为优异的光热剂被广泛使用。然而，关于 MXenes 作为声敏剂的报道有限。在此，制备了高熵 MXene (HEM)、TVNMC，用于产生抗甲氧西林耐药性 (MRSA) 的活性氧化物 (ROS)。有趣的是，TVNMC MXenes 的不同成分的能量储存和转换使得在美国照射下产生 ROS，甚至在光热疗法下增强。这种组合疗法几乎完全杀死并根除 MRSA 及其生物膜。此外，TVNMC MXene 同时消除了 MRSA 脓肿，同时在声动力和光热治疗下促进伤口愈合，对小鼠组织的异常影响可以忽略不计，这使得 TVNMC MXene 成为一种有前景的声敏剂，可用于生物医学用途。总体而言，该系统为高熵 MXene 作为新型声敏剂在抗感染治疗中的应用提供了巨大的潜力。