<br>用于四环素筛选的钙钛矿电化学发光适体传感器,Luminescence

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用于四环素筛选的钙钛矿电化学发光适体传感器
Luminescence ( IF 3.2 ) Pub Date : 2024-03-20 , DOI: 10.1002/bio.4717
Yuxin Chen ₁ , Xinyi Zhong ₁ , Qiling Yang ₁ , Huiping Chen ₁ , Nan Hao ₂ , Shanwen Hu ₁

Affiliation

四环素类抗生素是目前最常用的一类抗生素，其残留问题严重影响公共卫生安全。在这项研究中，用十六烷基三甲基溴化铵对钙钛矿进行表面修饰，在水性体系中产生稳定的电化学发光（ECL）发射体，并改善了钙钛矿的生物相容性。开发了一种基于钙钛矿量子点的 ECL 传感策略。利用抗生素相应的适配体，引发应变位移反应，破坏电极表面钙钛矿和银纳米团簇（Ag NCs）组成的ECL猝灭系统，产生信号，实现对几种常见四环素类抗生素的定量检测。钙钛矿量子点提供了强大而稳定的初始信号，而银簇的高效催化活性增强了识别灵敏度。以四环素、金四环素、土霉素为例，演示了该方法的区分和定量检测。此外，适配体传感器在实际样品中表现出线性范围（0.1-10 μM OTC）的分析性能和良好的回收率（94.7%至101.6%）。这种方法有可能成为评估抗生素残留的敏感且实用的方法。

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A perovskite‐based electrochemiluminescence aptasensor for tetracycline screening

Tetracyclines are currently the most commonly used class of antibiotics, and their residue issue significantly impacts public health safety. In this study, a surface modification of perovskite with cetyltrimethylammonium bromide led to the generation of stable electrochemiluminescence (ECL) emitters in aqueous systems and improved the biocompatibility of perovskite. A perovskite quantum dot‐based ECL sensing strategy was developed. Utilizing the corresponding aptamer of the antibiotics, strain displacement reactions were triggered, disrupting the ECL quenching system composed of perovskite and Ag nanoclusters (Ag NCs) on the electrode surface, generating a signal to achieve quantitative detection of several common tetracycline antibiotics. The perovskite quantum dot provided a strong and stable initial signal, while the efficient catalytic activity of the silver cluster enhanced the recognition sensitivity. Tetracycline, chlortetracycline, and oxytetracycline were used as examples to demonstrate the differentiation and quantitative detection through this method. In addition, the aptasensor exhibited analytical performance with the linear range (0.1–10 μM OTC) and good recovery rates of 94.7% to 101.6% in real samples. This approach has the potential to become a sensitive and practical approach for assessing antibiotic residues.

更新日期：2024-03-20

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