Antibacterial, Fatigue-Resistant, and Self-Healing Dressing from Natural-Based Composite Hydrogels for Infected Wound Healing,Biomacromolecules

当前位置： X-MOL 学术 › Biomacromolecules › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Antibacterial, Fatigue-Resistant, and Self-Healing Dressing from Natural-Based Composite Hydrogels for Infected Wound Healing
Biomacromolecules ( IF 5.5 ) Pub Date : 2024-03-19 , DOI: 10.1021/acs.biomac.3c01385
Ming Yan ₁ , Shi-Yu Hu ₁ , Zhi-Guo Wang ₂ , Rui Hong ₂ , Xu Peng ₃ , Maja Kuzmanović ₁ , Min Yang ₄ , Rui Dai ₅ , Yanqiong Wang ₆ , Juxiang Gou ₂ , Ka Li ₂ , Jia-Zhuang Xu _{1,

2} , Zhong-Ming Li ₁

Affiliation

The treatment of infected wounds faces substantial challenges due to the high incidence and serious infection-related complications. Natural-based hydrogel dressings with favorable antibacterial properties and strong applicability are urgently needed. Herein, we developed a composite hydrogel by constructing multiple networks and loading ciprofloxacin for infected wound healing. The hydrogel was synthesized via a Schiff base reaction between carboxymethyl chitosan and oxidized sodium alginate, followed by the polymerization of the acrylamide monomer. The resultant hydrogel dressing possessed a good self-healing ability, considerable compression strength, and reliable compression fatigue resistance. In vitro assessment showed that the composite hydrogel effectively eliminated bacteria and exhibited an excellent biocompatibility. In a model of Staphylococcus aureus-infected full-thickness wounds, wound healing was significantly accelerated without scars through the composite hydrogel by reducing wound inflammation. Overall, this study opens up a new way for developing multifunctional hydrogel wound dressings to treat wound infections.

中文翻译：

由天然复合水凝胶制成的抗菌、抗疲劳和自愈敷料，用于感染伤口愈合

由于感染伤口的高发病率和严重的感染相关并发症，感染伤口的治疗面临重大挑战。迫切需要具有良好抗菌性能和强适用性的天然水凝胶敷料。在此，我们通过构建多个网络并加载环丙沙星来开发一种复合水凝胶，用于感染伤口愈合。水凝胶是通过羧甲基壳聚糖和氧化的海藻酸钠之间的席夫碱反应合成的，然后是丙烯酰胺单体的聚合。所得的水凝胶敷料具有良好的自修复能力、相当大的压缩强度和可靠的抗压缩疲劳性。体外评估表明，复合水凝胶有效消灭细菌，并表现出优异的生物相容性。在金黄色葡萄球菌感染的全层伤口模型中，通过减少伤口炎症，通过复合水凝胶显着加速伤口愈合，而不会留下疤痕。总的来说，这项研究为开发多功能水凝胶伤口敷料治疗伤口感染开辟了一条新途径。

更新日期：2024-03-19

点击分享查看原文

点击收藏

阅读更多本刊新发论文本刊介绍/投稿指南