Photogenerated chlorine radicals activate C(sp3)–H bonds of alkylbenzenes to access quinazolinones,Organic & Biomolecular Chemistry

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Photogenerated chlorine radicals activate C(sp3)–H bonds of alkylbenzenes to access quinazolinones
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2024-03-20 , DOI: 10.1039/d4ob00129j
Xin-Yao Pan ₁ , Gui-Xia Sun ₁ , Fang-Ping Huang ₁ , Wen-Jian Qin ₁ , Qing-Hu Teng ₁ , Kai Wang ₁

Affiliation

An Fe-catalyzed visible-light induced condensation of alkylbenzenes with anthranilamides has been developed. Upon irradiation, the trivalent iron complex could generate chlorine radicals, which successfully abstracted the hydrogen of benzylic C–H bonds to form benzyl radicals. And these benzyl radicals were converted into oxygenated products under air conditions, which subsequently reacted with anthranilamides for the synthesis of quinazolinones.

中文翻译：

光生氯自由基激活烷基苯的C(sp3)–H键以形成喹唑啉酮

已经开发出一种铁催化的可见光诱导烷基苯与邻氨基苯甲酰胺的缩合反应。在辐照下，三价铁配合物可以产生氯自由基，氯自由基成功地夺取了苄基C-H键上的氢，形成了苄基自由基。这些苄基自由基在空气条件下转化为氧化产物，随后与邻氨基苯甲酰胺反应合成喹唑啉酮类化合物。

更新日期：2024-03-20

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