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Effects of the Molecular Structure of Malodor Substances and Their Masking on 1,2-Dioleoyl-sn-glycero-3-phosphocholine Molecular Layers
Langmuir ( IF 3.7 ) Pub Date : 2024-03-19 , DOI: 10.1021/acs.langmuir.3c03796 Mai Yotsumoto 1 , Risa Fujita 1 , Muneyuki Matsuo 1, 2 , Shinobu Nakanishi 3 , Mitsuhiro Denda 4 , Satoshi Nakata 1
Langmuir ( IF 3.7 ) Pub Date : 2024-03-19 , DOI: 10.1021/acs.langmuir.3c03796 Mai Yotsumoto 1 , Risa Fujita 1 , Muneyuki Matsuo 1, 2 , Shinobu Nakanishi 3 , Mitsuhiro Denda 4 , Satoshi Nakata 1
Affiliation
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Certain odors have been shown not only to cause health problems and stress but also to affect skin barrier function. Therefore, it is important to understand olfactory masking to develop effective fragrances to mask malodors. However, olfaction and olfactory masking mechanisms are not yet fully understood. To understand the mechanism of the masking effect that has been studied, the responses of several target substance (TS) molecules–1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) mixed molecular layers to odorant (OD) molecules were examined as a simple experimental model of epithelial cellular membranes injured by TS molecules. Here, we examined trans-2-nonenal, 1-nonanal, trans-2-decenal, and 1-decanal as TS molecules to clarify the effects of double bonds and hydrocarbon chain lengths on the phospholipid molecular layer. In addition, benzaldehyde and cyclohexanecarboxaldehyde were utilized as OD molecules to clarify the masking effect of the aromatic ring. Surface pressure (Π)–area (A) isotherms were measured to clarify the adsorption or desorption of TS and OD molecules on the DOPC molecular layer. In addition, Fourier transform infrared spectroscopy was performed to clarify the interactions among DOPC, TS, and OD molecules. We found that TS molecules with and without double bonds had different effects on the DOPC molecular layer and that molecules with shorter chain lengths had greater effects on the DOPC molecular layer. Furthermore, OD molecules with aromatic rings counteracted the effects of the TS molecules. On the basis of this research, not only a detailed mechanism by which odor molecules affect lipid membranes without mediating olfactory receptors is elucidated but also more effective OD molecules with masking effects are proposed.
中文翻译：
恶臭物质的分子结构及其对1,2-二油酰-sn-甘油-3-磷酸胆碱分子层掩蔽的影响
某些气味不仅会导致健康问题和压力，还会影响皮肤屏障功能。因此，了解嗅觉掩蔽对于开发有效的香料来掩盖恶臭非常重要。然而，嗅觉和嗅觉掩蔽机制尚未完全了解。为了了解已研究的掩蔽效应的机制，研究了几种目标物质（TS）分子——1,2-二油酰-sn-甘油-3-磷酸胆碱（DOPC）混合分子层对气味剂（OD）分子的响应作为 TS 分子损伤的上皮细胞膜的简单实验模型进行检查。在这里，我们检查了反式-2-壬烯醛、1-壬醛、反式-2-癸烯醛和1-癸醛作为TS分子，以阐明双键和烃链长度对磷脂分子层的影响。此外，利用苯甲醛和环己烷甲醛作为OD分子来阐明芳环的掩蔽效应。测量表面压力（ Π ）-面积（ A ）等温线，以阐明 TS 和 OD 分子在 DOPC 分子层上的吸附或解吸。此外，还进行了傅里叶变换红外光谱分析，以阐明 DOPC、TS 和 OD 分子之间的相互作用。我们发现带双键和不带双键的TS分子对DOPC分子层的影响不同，链长较短的分子对DOPC分子层的影响更大。此外，带有芳香环的OD分子抵消了TS分子的影响。 在此研究的基础上，不仅阐明了气味分子在不介导嗅觉受体的情况下影响脂膜的详细机制，而且还提出了更有效的具有掩蔽作用的OD分子。
更新日期：2024-03-19
中文翻译：
恶臭物质的分子结构及其对1,2-二油酰-sn-甘油-3-磷酸胆碱分子层掩蔽的影响
某些气味不仅会导致健康问题和压力，还会影响皮肤屏障功能。因此，了解嗅觉掩蔽对于开发有效的香料来掩盖恶臭非常重要。然而，嗅觉和嗅觉掩蔽机制尚未完全了解。为了了解已研究的掩蔽效应的机制，研究了几种目标物质（TS）分子——1,2-二油酰-sn-甘油-3-磷酸胆碱（DOPC）混合分子层对气味剂（OD）分子的响应作为 TS 分子损伤的上皮细胞膜的简单实验模型进行检查。在这里，我们检查了反式-2-壬烯醛、1-壬醛、反式-2-癸烯醛和1-癸醛作为TS分子，以阐明双键和烃链长度对磷脂分子层的影响。此外，利用苯甲醛和环己烷甲醛作为OD分子来阐明芳环的掩蔽效应。测量表面压力（ Π ）-面积（ A ）等温线，以阐明 TS 和 OD 分子在 DOPC 分子层上的吸附或解吸。此外，还进行了傅里叶变换红外光谱分析，以阐明 DOPC、TS 和 OD 分子之间的相互作用。我们发现带双键和不带双键的TS分子对DOPC分子层的影响不同，链长较短的分子对DOPC分子层的影响更大。此外，带有芳香环的OD分子抵消了TS分子的影响。 在此研究的基础上，不仅阐明了气味分子在不介导嗅觉受体的情况下影响脂膜的详细机制，而且还提出了更有效的具有掩蔽作用的OD分子。
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