Controlled and Site-Selective C–H/N–H Alkenylation, Dialkenylation, and Dehydrogenative β-Alkenylation of Various N-Heterocycles,The Journal of Organic Chemistry

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Controlled and Site-Selective C–H/N–H Alkenylation, Dialkenylation, and Dehydrogenative β-Alkenylation of Various N-Heterocycles
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2024-03-19 , DOI: 10.1021/acs.joc.4c00064
Jin Yan ₁ , Suijie Zhong ₁ , Xu Chen ₁ , Yihuan Luo ₁ , Hua Cao ₁ , Xiang Liu ₁ , Limin Zhao ₁

Affiliation

Here, we report controlled and site-selective C–H alkenylation and dialkenylation of indolizines and pyrrolo[1,2-a]quinolines with β-alkoxyvinyl trifluoromethylketones under simple and practical conditions. Moreover, this direct C–H alkenylation strategy can also be extended to imidazo[1,2-a]pyridines. Notably, without a transition metal and external oxidant, efficient dehydrogenative β-alkenylation of tertiary amines with β-alkoxyvinyl trifluoromethylketones is presented.

中文翻译：

各种 N-杂环的受控和位点选择性 C–H/N–H 烯基化、二烯基化和脱氢 β-烯基化

在这里，我们报告了在简单实用的条件下，中氮茚和吡咯并[1,2- a ]喹啉与β-烷氧基乙烯基三氟甲基酮的受控和位点选择性C-H烯基化和二烯基化反应。此外，这种直接的C-H烯基化策略也可以扩展到咪唑并[1,2- a ]吡啶。值得注意的是，在没有过渡金属和外部氧化剂的情况下，叔胺与β-烷氧基乙烯基三氟甲基酮进行有效的脱氢β-烯基化。

更新日期：2024-03-19

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