Inceptor (encoded by Iir) is a novel receptor that inhibits insulin receptor and insulin-like growth factor signalling. A previous study showed that loss of inceptor from β-cells in lean normoglycaemic mice improved glucose homeostasis. Now, the same group reports findings on inceptor loss in mouse models of obesity.

Inceptor is widely expressed in neurons and pan-neuronal Iir deletion in male DIO mice also improved glucose tolerance compared with wild-type control mice. Interestingly, however, these same effects were not seen with targeted deletion of Iir from AgRP neurons and POMC neurons (which are key for glucose control). Thus, the mechanisms causing improvements in mice with neuronal inceptor loss are still unclear. Finally, targeted adult-onset deletion of Iir from β-cells in DIO male mice also improves β-cell function and glucose control, corroborating findings from the previous study.

Inceptor（由Iir编码）是一种抑制胰岛素受体和胰岛素样生长因子信号传导的新型受体。先前的一项研究表明，瘦血糖正常小鼠的β细胞感受器缺失可改善葡萄糖稳态。现在，同一小组报告了肥胖小鼠模型中感受器丢失的发现。

Inceptor在神经元中广泛表达，与野生型对照小鼠相比，雄性DIO小鼠的全神经元Iir缺失也改善了葡萄糖耐量。然而有趣的是，从 AgRP 神经元和 POMC 神经元（血糖控制的关键）中定向删除Iir并没有观察到这些相同的效果。因此，神经元受体缺失小鼠的改善机制仍不清楚。最后，在 DIO 雄性小鼠的 β 细胞中进行成年发病时有针对性的Iir缺失也能改善 β 细胞功能和血糖控制，证实了之前研究的结果。