New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies,Journal of Enzyme inhibition and Medicinal Chemistry

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New imidazole-2-thiones linked to acenaphythylenone as dual DNA intercalators and topoisomerase II inhibitors: structural optimization, docking, and apoptosis studies
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-03-15 , DOI: 10.1080/14756366.2024.2311818
Asmaa H Mohamed ₁ , Mohammed B Alshammari ₂ , Ashraf A Aly ₁ , Kamal U Sadek ₁ , Akil Ahmad ₂ , Eman A Aziz ₁ , Amira F El-Yazbi ₃ , Eman J El-Agroudy ₄ , Marwa E Abdelaziz ₄

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In this article, a new series of 2-((3,5-disubstituted-2-thioxo-imidazol-1-yl)imino)acenaphthylen-1(2H)-ones were synthesized. Imidazole-2-thione with acenaphthylen-one gave a hybrid scaffold that ...

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