Understanding and meticulously engineering the biomolecular corona on the surface of lipid nanoparticles can accelerate their successful clinical applications beyond mRNA vaccines. We outline the major hurdles of clinical development faced by lipid nanoparticles and discuss how considering and modifying the biomolecular corona could mitigate these challenges.

中文翻译：

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生物分子冠的精确工程加速脂质纳米颗粒的临床转化


了解并精心设计脂质纳米粒子表面的生物分子冠可以加速其在 mRNA 疫苗之外的成功临床应用。我们概述了脂质纳米粒子临床开发面临的主要障碍，并讨论了如何考虑和修改生物分子冠可以缓解这些挑战。