Modulating and Accelerating Photolysis of Photoactivatable [2.2]Paracyclophane Aryl Azide in Supramolecular Host for Bioimaging,Advanced Functional Materials

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Modulating and Accelerating Photolysis of Photoactivatable [2.2]Paracyclophane Aryl Azide in Supramolecular Host for Bioimaging
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2024-03-15 , DOI: 10.1002/adfm.202401938
Xujun Qiu ₁ , Eric Pohl ₂ , Qianyu Cai ₁ , Jasmin Seibert ₁ , Yuting Li ₁ , Sonja Leopold ₂ , Olaf Fuhr _{3,

4} , Michael A. R. Meier _{1,

5} , Ute Schepers _{1,

2} , Stefan Bräse _{1,

5}

Affiliation

Photolysis of aryl azides offers a versatile approach to achieve more sophisticated functionalization, for instance in the field of chemical biology. In this study, a photoactivatable aryl azide named Pcp-Az is presented that forms three distinct emissive molecules after irradiation. Computational studies unveiled that the photolysis of Pcp-Az in aqueous medium undergoes different reaction channels, leading to the three mentioned distinct products. When the photoreaction is performed using the supramolecular host cucurbit[8]uril(CB8) for Pcp-Az, the reaction is found to be tuned and accelerated. Finally, the potential application of the photoproducts are showcased in bioimaging, and also the time-dependent photoactivating imaging.

中文翻译：

调节和加速可光活化[2.2]对环芳芳基叠氮化物在超分子宿主中的光解用于生物成像

芳基叠氮化物的光解提供了一种实现更复杂功能化的通用方法，例如在化学生物学领域。在这项研究中，提出了一种名为Pcp-Az的光活化芳基叠氮化物，它在照射后形成三种不同的发射分子。计算研究表明， Pcp-Az在水介质中的光解经历了不同的反应通道，产生了上述三种不同的产物。当使用Pcp-Az的超分子主体葫芦[8]uril(CB8)进行光反应时，发现反应被调节和加速。最后，展示了光产品在生物成像以及时间依赖性光活化成像中的潜在应用。

更新日期：2024-03-15

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