Bioengineering toolkits for potentiating organoid therapeutics,Advanced Drug Delivery Reviews

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Bioengineering toolkits for potentiating organoid therapeutics
Advanced Drug Delivery Reviews ( IF 15.2 ) Pub Date : 2024-03-05 , DOI: 10.1016/j.addr.2024.115238
Sewon Park ₁ , Seung-Woo Cho ₂

Affiliation

Organoids are three-dimensional, multicellular constructs that recapitulate the structural and functional features of specific organs. Because of these characteristics, organoids have been widely applied in biomedical research in recent decades. Remarkable advancements in organoid technology have positioned them as promising candidates for regenerative medicine. However, current organoids still have limitations, such as the absence of internal vasculature, limited functionality, and a small size that is not commensurate with that of actual organs. These limitations hinder their survival and regenerative effects after transplantation. Another significant concern is the reliance on mouse tumor-derived matrix in organoid culture, which is unsuitable for clinical translation due to its tumor origin and safety issues. Therefore, our aim is to describe engineering strategies and alternative biocompatible materials that can facilitate the practical applications of organoids in regenerative medicine. Furthermore, we highlight meaningful progress in organoid transplantation, with a particular emphasis on the functional restoration of various organs.

中文翻译：

用于增强类器官治疗的生物工程工具包

类器官是三维多细胞结构，概括了特定器官的结构和功能特征。由于这些特性，类器官近几十年来在生物医学研究中得到了广泛的应用。类器官技术的显着进步使它们成为再生医学的有希望的候选者。然而，目前的类器官仍然存在局限性，例如缺乏内部脉管系统、功能有限以及尺寸小与实际器官不相称。这些限制阻碍了它们在移植后的存活和再生效果。另一个值得关注的问题是类器官培养中对小鼠肿瘤衍生基质的依赖，由于其肿瘤起源和安全性问题，不适合临床转化。因此，我们的目标是描述工程策略和替代生物相容性材料，以促进类器官在再生医学中的实际应用。此外，我们强调类器官移植方面取得的有意义的进展，特别强调各种器官的功能恢复。

更新日期：2024-03-05

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