Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic remodeling of the atria and is the substrate for development of atrial fibrillation, the most common arrhythmia. Pathophysiologic mechanisms driving atrial myopathy are inflammation, oxidative stress, atrial stretch, and neurohormonal signals, e.g., angiotensin-II and aldosterone. These mechanisms initiate the structural and functional remodeling of the atrial myocardium. Novel therapeutic strategies are being developed that target the pathophysiologic mechanisms of atrial myopathy. In this review, we will discuss the pathophysiology of atrial myopathy, as well as diagnostic and therapeutic strategies.

心房肌病是一种由心房的电性、结构性、收缩性和自主性重塑组成的疾病，是房颤（最常见的心律失常）发生的基础。驱动心房肌病的病理生理机制是炎症、氧化应激、心房牵张和神经激素信号，例如血管紧张素-II 和醛固酮。这些机制启动心房心肌的结构和功能重塑。针对心房肌病病理生理机制的新治疗策略正在开发中。在这篇综述中，我们将讨论心房肌病的病理生理学以及诊断和治疗策略。